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Single-cell immune profiling reveals markers of emergency myelopoiesis that distinguish severe from mild respiratory syncytial virus disease in infants.
Zivanovic, Nevena; Öner, Deniz; Abraham, Yann; McGinley, Joseph; Drysdale, Simon B; Wildenbeest, Joanne G; Crabbe, Marjolein; Vanhoof, Greet; Thys, Kim; Thwaites, Ryan S; Robinson, Hannah; Bont, Louis; Openshaw, Peter J M; Martinón-Torres, Federico; Pollard, Andrew J; Aerssens, Jeroen.
Afiliación
  • Zivanovic N; Discovery Sciences & Translational Biomarkers Infectious Diseases, Janssen Research and Development, Beerse, Belgium.
  • Öner D; Discovery Sciences & Translational Biomarkers Infectious Diseases, Janssen Research and Development, Beerse, Belgium.
  • Abraham Y; Discovery Sciences & Translational Biomarkers Infectious Diseases, Janssen Research and Development, Beerse, Belgium.
  • McGinley J; Department of Paediatrics, Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, University of Oxford, London, UK.
  • Drysdale SB; Centre for Neonatal and Paediatric Infection, Institute for Infection and Immunity, St George's, University of London, London, UK.
  • Wildenbeest JG; Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Crabbe M; Discovery Sciences & Translational Biomarkers Infectious Diseases, Janssen Research and Development, Beerse, Belgium.
  • Vanhoof G; Discovery Sciences & Translational Biomarkers Infectious Diseases, Janssen Research and Development, Beerse, Belgium.
  • Thys K; Discovery Sciences & Translational Biomarkers Infectious Diseases, Janssen Research and Development, Beerse, Belgium.
  • Thwaites RS; Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
  • Robinson H; Department of Paediatrics, Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, University of Oxford, London, UK.
  • Bont L; Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Openshaw PJM; Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
  • Martinón-Torres F; Pediatrics Department, Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Galicia, Spain.
  • Pollard AJ; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
Clin Transl Med ; 13(12): e1507, 2023 12.
Article en En | MEDLINE | ID: mdl-38115705
ABSTRACT
Whereas most infants infected with respiratory syncytial virus (RSV) show no or only mild symptoms, an estimated 3 million children under five are hospitalized annually due to RSV disease. This study aimed to investigate biological mechanisms and associated biomarkers underlying RSV disease heterogeneity in young infants, enabling the potential to objectively categorize RSV-infected infants according to their medical needs. Immunophenotypic and functional profiling demonstrated the emergence of immature and progenitor-like neutrophils, proliferative monocytes (HLA-DRLow , Ki67+), impaired antigen-presenting function, downregulation of T cell response and low abundance of HLA-DRLow B cells in severe RSV disease. HLA-DRLow monocytes were found as a hallmark of RSV-infected infants requiring hospitalization. Complementary transcriptomics identified genes associated with disease severity and pointed to the emergency myelopoiesis response. These results shed new light on mechanisms underlying the pathogenesis and development of severe RSV disease and identified potential new candidate biomarkers for patient stratification.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Virus Sincitial Respiratorio / Mielopoyesis Límite: Child / Humans / Infant Idioma: En Revista: Clin Transl Med Año: 2023 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Virus Sincitial Respiratorio / Mielopoyesis Límite: Child / Humans / Infant Idioma: En Revista: Clin Transl Med Año: 2023 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos