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Poor prognosis of young male patients with stage III colorectal cancer: A multicenter retrospective study.
Okamoto, Kazuaki; Sasaki, Kazuhito; Nozawa, Hiroaki; Murono, Koji; Emoto, Shigenobu; Yamauchi, Shinichi; Sugihara, Kenichi; Ishihara, Soichiro.
Afiliación
  • Okamoto K; Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
  • Sasaki K; Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
  • Nozawa H; Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
  • Murono K; Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
  • Emoto S; Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
  • Yamauchi S; Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
  • Sugihara K; Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
  • Ishihara S; Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
J Surg Oncol ; 129(4): 785-792, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38115553
ABSTRACT
BACKGROUND AND

OBJECTIVES:

The number of young patients with colorectal cancer (CRC) is increasing. However, sex-dependent differences in the prognosis of young CRC remain unknown.

METHODS:

We investigated patients aged <70 years with stage III CRC treated between January 2000 and December 2010 in 24 Japanese referral hospitals. Patients were divided into subgroups by age of 50 years (early-onset and late-onset groups) and sex, and clinical characteristics and survival outcomes were compared. Risk factors associated with poor survival outcomes were also analyzed.

RESULTS:

Among 4758 consecutive patients, 771 (16%) were <50 years. Regardless of sex, there were more patients with rectal cancer and treated with adjuvant chemotherapy in the early-onset group. Among males, tumors in the early-onset group were poorly differentiated (p < 0.001), and patients were diagnosed at an advanced N stage (p = 0.010). Among females, there were more patients with left-sided cancer in the early-onset group (p < 0.001). Relapse-free survival (RFS) and overall survival (OS) were worse in the early-onset group than in the late-onset group (5-year RFS rates 58% and 63%, p = 0.024; 5-year OS rates 76% and 81%, p = 0.041, respectively), while there were no age-dependent differences in the survival outcomes of female CRC patients. A multivariate analysis identified age <50 years as one of the independent risk factors associated with poor RFS in male stage III CRC patients (p = 0.032)

CONCLUSIONS:

Young male patients with stage III CRC showed poorer survival outcomes than their older counterparts. Therefore, age- and sex-related differences in the incidence of CRC recurrence need to be considered.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales Límite: Female / Humans / Male Idioma: En Revista: J Surg Oncol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales Límite: Female / Humans / Male Idioma: En Revista: J Surg Oncol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos