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Gastric acid-responsive deformable sodium alginate/Bletilla striata polysaccharide in situ gel for the protection and treatment of alcohol-induced peptic ulcers.
Fan, Yilin; Hong, Ran; Sun, Xiaoli; Luo, Qiaomei; Wei, Huilin; Chen, Yajuan; Zhang, Zengni; Zhou, Xia; Wan, Jun.
Afiliación
  • Fan Y; School of Life Science and Engineering, Southwest Jiaotong University, 610031, China.
  • Hong R; School of Life Science and Engineering, Southwest Jiaotong University, 610031, China.
  • Sun X; School of Life Science and Engineering, Southwest Jiaotong University, 610031, China.
  • Luo Q; School of Life Science and Engineering, Southwest Jiaotong University, 610031, China.
  • Wei H; School of Life Science and Engineering, Southwest Jiaotong University, 610031, China.
  • Chen Y; School of Life Science and Engineering, Southwest Jiaotong University, 610031, China.
  • Zhang Z; School of Life Science and Engineering, Southwest Jiaotong University, 610031, China.
  • Zhou X; School of Life Science and Engineering, Southwest Jiaotong University, 610031, China.
  • Wan J; School of Life Science and Engineering, Southwest Jiaotong University, 610031, China. Electronic address: wjun1013@swjtu.edu.cn.
Int J Biol Macromol ; 258(Pt 1): 128815, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38114010
ABSTRACT
First-line drugs for peptic ulcer (PU) treatment are typically limited by poor targeting and adverse effects associated with long-term use. Despite recent advancements in novel therapeutic approaches for PU, the development of sustained-release delivery systems tailored to specific pathological characteristics remains challenging. Persistent inflammation, particularly gastric inflammatory microenvironment imbalance, characterizes the PU. In this study, we prepared an in situ gel composed of sodium alginate, deacetylated gellan gum, calcium citrate, and Bletilla striata polysaccharide (BSP) to achieve sustained release of BSP. The BSP in situ gel demonstrated favorable fluidity in vitro and completed self-assembly in vivo in response to the acidic milieu at a pH of 1.5. Furthermore, the shear, extrusion, and deformation properties increased by 26.4 %, 103.7 %, and 46.3 %, respectively, with long-term gastric retention (4 h) and mucosal adaptation. Animal experiments confirmed that the BSP in situ gel could attenuate necrotic injury and inflammatory cell infiltration, maintain mucosal barrier integrity, regulate cytokine imbalance and inflammation-associated hyperapoptosis, thus effectively alleviate the inflammatory microenvironmental imbalance in PU without significant side effects. Overall, our findings demonstrated that the BSP in situ gel is a promising therapeutic strategy for PU and opens avenues for developing self-assembled formulations targeting the pathological features of PUs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Úlcera Péptica / Orchidaceae Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Úlcera Péptica / Orchidaceae Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos