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Differences in the gut microbiota between Gurkhas and soldiers of British origin.
Troth, Thomas D; McInnes, Ross S; Dunn, Steven J; Mirza, Jeremy; Whittaker, Annalise H; Goodchild, Sarah A; Loman, Nicholas J; Harding, Sarah V; van Schaik, Willem.
Afiliación
  • Troth TD; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
  • McInnes RS; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
  • Dunn SJ; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
  • Mirza J; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
  • Whittaker AH; CBR Division, Defence and Science Technology Laboratory, Salisbury, Wiltshire, United Kingdom.
  • Goodchild SA; CBR Division, Defence and Science Technology Laboratory, Salisbury, Wiltshire, United Kingdom.
  • Loman NJ; Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
  • Harding SV; CBR Division, Defence and Science Technology Laboratory, Salisbury, Wiltshire, United Kingdom.
  • van Schaik W; School of Respiratory Sciences, University of Leicester, Leicester, United Kingdom.
PLoS One ; 18(12): e0292645, 2023.
Article en En | MEDLINE | ID: mdl-38113233
ABSTRACT
Previous work indicated that the incidence of travellers' diarrhoea (TD) is higher in soldiers of British origin, when compared to soldiers of Nepalese descent (Gurkhas). We hypothesise that the composition of the gut microbiota may be a contributing factor in the risk of developing TD in soldiers of British origin. This study aimed to characterise the gut microbial composition of Gurkha and non-Gurkha soldiers of the British Army. Recruitment of 38 soldiers (n = 22 Gurkhas, n = 16 non-Gurkhas) and subsequent stool collection, enabled shotgun metagenomic sequencing-based analysis of the gut microbiota. The microbiota of Gurkhas had significantly (P < 0.05) lower diversity, for both Shannon and Simpson diversity indices, using species level markers than the gut microbiota of non-Gurkha soldiers. Non-metric Multidimensional Scaling (NMDS) of the Bray-Curtis distance matrix revealed a significant difference in the composition of the gut microbiota between Gurkhas and non-Gurkha soldiers, at both the species level (P = 0.0178) and the genus level (P = 0.0483). We found three genera and eight species that were significantly enriched in the non-Gurkha group and one genus (Haemophilus) and one species (Haemophilus parainfluenzae) which were enriched in the Gurkha group. The difference in the microbiota composition between Gurkha soldiers and soldiers of British origin may contribute to higher colonization resistance against diarrhoeal pathogens in the former group. Our findings may enable further studies into interventions that modulate the gut microbiota of soldiers to prevent TD during deployment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microbioma Gastrointestinal / Personal Militar Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microbioma Gastrointestinal / Personal Militar Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos