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CD115+ monocytes protect microbially experienced mice against E. coli-induced sepsis.
Martin, Matthew D; Skon-Hegg, Cara; Kim, Caleb Y; Xu, Julie; Kucaba, Tamara A; Swanson, Whitney; Pierson, Mark J; Williams, Jesse W; Badovinac, Vladimir P; Shen, Steven S; Ingersoll, Molly A; Griffith, Thomas S.
Afiliación
  • Martin MD; Department of Urology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Skon-Hegg C; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Kim CY; These authors contributed equally.
  • Xu J; Department of Urology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Kucaba TA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Swanson W; These authors contributed equally.
  • Pierson MJ; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Williams JW; Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, MN 55455, USA.
  • Badovinac VP; Department of Urology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Shen SS; Department of Urology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Ingersoll MA; Department of Urology, University of Minnesota, Minneapolis, MN 55455, USA.
  • Griffith TS; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Cell Rep ; 42(11)2023 11 28.
Article en En | MEDLINE | ID: mdl-38111515
ABSTRACT
Uropathogenic E. coli (UPEC) is a primary organism responsible for urinary tract infections and a common cause of sepsis. Microbially experienced laboratory mice, generated by cohousing with pet store mice, exhibit increased morbidity and mortality to polymicrobial sepsis or lipopolysaccharide challenge. By contrast, cohoused mice display significant resistance, compared with specific pathogen-free mice, to a monomicrobial sepsis model using UPEC. CD115+ monocytes mediate protection in the cohoused mice, as depletion of these cells leads to increased mortality and UPEC pathogen burden. Further study of the cohoused mice reveals increased TNF-α production by monocytes, a skewing toward Ly6ChiCD115+ "classical" monocytes, and enhanced egress of Ly6ChiCD115+ monocytes from the bone marrow. Analysis of cohoused bone marrow also finds increased frequency and number of myeloid multipotent progenitor cells. These results show that a history of microbial exposure impacts innate immunity in mice, which can have important implications for the preclinical study of sepsis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Urinarias / Sepsis / Infecciones por Escherichia coli / Escherichia coli Uropatógena Límite: Animals Idioma: En Revista: Cell Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Urinarias / Sepsis / Infecciones por Escherichia coli / Escherichia coli Uropatógena Límite: Animals Idioma: En Revista: Cell Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos