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Intranasal mask for protecting the respiratory tract against viral aerosols.
Hu, Xiaoming; Wang, Shuang; Fu, Shaotong; Qin, Meng; Lyu, Chengliang; Ding, Zhaowen; Wang, Yan; Wang, Yishu; Wang, Dongshu; Zhu, Li; Jiang, Tao; Sun, Jing; Ding, Hui; Wu, Jie; Chang, Lingqian; Cui, Yimin; Pang, Xiaocong; Wang, Youchun; Huang, Weijin; Yang, Peidong; Wang, Limin; Ma, Guanghui; Wei, Wei.
Afiliación
  • Hu X; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China.
  • Wang S; School of Chemical Engineering, University of Chinese Academy of Sciences, 100049, Beijing, China.
  • Fu S; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China.
  • Qin M; School of Chemical Engineering, University of Chinese Academy of Sciences, 100049, Beijing, China.
  • Lyu C; School of Chemical Engineering, University of Chinese Academy of Sciences, 100049, Beijing, China.
  • Ding Z; State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China.
  • Wang Y; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, 100029, Beijing, China.
  • Wang Y; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China.
  • Wang D; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China.
  • Zhu L; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China.
  • Jiang T; School of Chemical Engineering, University of Chinese Academy of Sciences, 100049, Beijing, China.
  • Sun J; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China.
  • Ding H; School of Chemical Engineering, University of Chinese Academy of Sciences, 100049, Beijing, China.
  • Wu J; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, 100071, Beijing, China.
  • Chang L; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, 100071, Beijing, China.
  • Cui Y; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 100071, Beijing, China.
  • Pang X; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 100029, Beijing, China.
  • Wang Y; Shenzhen Key Laboratory of Nanozymes and Translational Cancer Research, Department of Otolaryngology, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, 518035, Shenzhen, China.
  • Huang W; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China.
  • Yang P; School of Chemical Engineering, University of Chinese Academy of Sciences, 100049, Beijing, China.
  • Wang L; Key Laboratory of Biomechanics and Mechanobiology, Ministry of Education Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical Engineering, Beihang University, 100083, Beijing, China.
  • Ma G; Department of Pharmacy, Peking University First Hospital, 100034, Beijing, China.
  • Wei W; Institute of Clinical Pharmacology, Peking University, 100191, Beijing, China.
Nat Commun ; 14(1): 8398, 2023 Dec 18.
Article en En | MEDLINE | ID: mdl-38110357
ABSTRACT
The spread of many infectious diseases relies on aerosol transmission to the respiratory tract. Here we design an intranasal mask comprising a positively-charged thermosensitive hydrogel and cell-derived micro-sized vesicles with a specific viral receptor. We show that the positively charged hydrogel intercepts negatively charged viral aerosols, while the viral receptor on vesicles mediates the entrapment of viruses for inactivation. We demonstrate that when displaying matched viral receptors, the intranasal masks protect the nasal cavity and lung of mice from either severe acute respiratory syndrome coronavirus 2 or influenza A virus. With computerized tomography images of human nasal cavity, we further conduct computational fluid dynamics simulation and three-dimensional printing of an anatomically accurate human nasal cavity, which is connected to human lung organoids to generate a human respiratory tract model. Both simulative and experimental results support the suitability of intranasal masks in humans, as the likelihood of viral respiratory infections induced by different variant strains is dramatically reduced.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virosis / Aerosoles y Gotitas Respiratorias Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virosis / Aerosoles y Gotitas Respiratorias Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido