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Tailored Coatings for Enhanced Performance of Zinc-Magnesium Alloys in Absorbable Implants.
Hernández-Escobar, David; Pajares-Chamorro, Natalia; Chatzistavrou, Xanthippi; Hankenson, Kurt D; Hammer, Neal D; Boehlert, Carl J.
Afiliación
  • Hernández-Escobar D; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824, United States.
  • Pajares-Chamorro N; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824, United States.
  • Chatzistavrou X; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824, United States.
  • Hankenson KD; Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
  • Hammer ND; Department of Orthopedic Surgery, University of Michigan, Ann Arbor, Michigan 48104, United States.
  • Boehlert CJ; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, United States.
ACS Biomater Sci Eng ; 10(1): 338-354, 2024 01 08.
Article en En | MEDLINE | ID: mdl-38109649
ABSTRACT
Absorbable metals exhibit potential for next-generation temporary medical implants, dissolving safely in the body during tissue healing and regeneration. Their commercial incorporation could substantially diminish the need for additional surgeries and complications that are tied to permanent devices. Despite extensive research on magnesium (Mg) and iron (Fe), achieving the optimal combination of mechanical properties, biocompatibility, and controlled degradation rate for absorbable implants remains a challenge. Zinc (Zn) and Zn-based alloys emerged as an attractive alternative for absorbable implants, due to favorable combination of in vivo biocompatibility and degradation behavior. Moreover, the development of suitable coatings can enhance their biological characteristics and tailor their degradation process. In this work, four different biodegradable coatings (based on zinc phosphate (ZnP), collagen (Col), and Ag-doped bioactive glass nanoparticles (AgBGNs)) were synthesized by chemical conversion, spin-coating, or a combination of both on Zn-3Mg substrates. This study assessed the impact of the coatings on in vitro degradation behavior, cytocompatibility, and antibacterial activity. The ZnP-coated samples demonstrated controlled weight loss and a decreased corrosion rate over time, maintaining a physiological pH. Extracts from the uncoated, ZnP-coated, and Col-AgBGN-coated samples showed higher cell viability with increasing concentration. Bacterial viability was significantly impaired in all coated samples, particularly in the Col-AgBGN coating. This study showcases the potential of a strategic material-coating combination to effectively tackle multiple challenges encountered in current medical implant technologies by modifying the properties of absorbable metals to tailor patient treatments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles Revestidos / Magnesio Límite: Humans Idioma: En Revista: ACS Biomater Sci Eng Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles Revestidos / Magnesio Límite: Humans Idioma: En Revista: ACS Biomater Sci Eng Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos