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The involvement of the gut microbiota in postoperative cognitive dysfunction based on integrated metagenomic and metabolomics analysis.
Zhang, Shi-Hua; Jia, Xiao-Yu; Wu, Qing; Jin, Jia; Xu, Long-Sheng; Yang, Lei; Han, Jun-Gang; Zhou, Qing-He.
Afiliación
  • Zhang S-h; Department of Anesthesiology and Pain Medicine, The Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang, China.
  • Jia X-y; College of Life Science and Medicine, Zhejiang Sci-Tech University , Hangzhou, Zhejiang, China.
  • Wu Q; Department of Anesthesiology and Pain Medicine, The Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang, China.
  • Jin J; Department of Anesthesiology and Pain Medicine, The Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang, China.
  • Xu L-s; College of Life Science and Medicine, Zhejiang Sci-Tech University , Hangzhou, Zhejiang, China.
  • Yang L; College of Life Science and Medicine, Zhejiang Sci-Tech University , Hangzhou, Zhejiang, China.
  • Han J-g; Department of Anesthesiology and Pain Medicine, The Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang, China.
  • Zhou Q-h; Department of Anesthesiology and Pain Medicine, The Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang, China.
Microbiol Spectr ; 11(6): e0310423, 2023 Dec 12.
Article en En | MEDLINE | ID: mdl-38108273
ABSTRACT
IMPORTANCE As the population ages and medical technology advances, anesthesia procedures for elderly patients are becoming more common, leading to an increased prevalence of postoperative cognitive dysfunction. However, the etiology and correlation between the gut microbiota and cognitive dysfunction are poorly understood, and research in this area is limited. In this study, mice with postoperative cognitive dysfunction were found to have reduced levels of fatty acid production and anti-inflammatory flora in the gut, and Bacteroides was associated with increased depression, leading to cognitive dysfunction and depression. Furthermore, more specific microbial species were identified in the disease model, suggesting that modulation of host metabolism through gut microbes may be a potential avenue for preventing postoperative cognitive dysfunction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disfunción Cognitiva / Microbioma Gastrointestinal / Complicaciones Cognitivas Postoperatorias Límite: Aged / Animals / Humans Idioma: En Revista: Microbiol Spectr Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disfunción Cognitiva / Microbioma Gastrointestinal / Complicaciones Cognitivas Postoperatorias Límite: Aged / Animals / Humans Idioma: En Revista: Microbiol Spectr Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos