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Pilot Study on Gut Microbiota Profile in Indian Children with Type 1 Diabetes.
Shah, Nikhil; Kulkarni, Abhijit; Mongad, Dattatray; Jaani, Kunal; Kajale, Neha; Tamahane, Vaishali; Bhor, Shital; Ladkat, Dipali; Khadilkar, Vaman; Gondhalekar, Ketan; Shouche, Yogesh; Khadilkar, Anuradha V.
Afiliación
  • Shah N; Department of Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.
  • Kulkarni A; Department of Pediatrics, Cloudnine Hospital, Malad, Mumbai, Maharashtra, India.
  • Mongad D; National Centre for Cell Science (NCCS), Pune, Maharashtra, India.
  • Jaani K; National Centre for Cell Science (NCCS), Pune, Maharashtra, India.
  • Kajale N; National Centre for Cell Science (NCCS), Pune, Maharashtra, India.
  • Tamahane V; Department of Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.
  • Bhor S; Department of Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.
  • Ladkat D; Department of Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.
  • Khadilkar V; Department of Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.
  • Gondhalekar K; Department of Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.
  • Shouche Y; Interdisciplinary School of Health Sciences, Savitribai Phule Pune University, Pune, Maharashtra, India.
  • Khadilkar AV; Department of Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.
Indian J Endocrinol Metab ; 27(5): 404-409, 2023.
Article en En | MEDLINE | ID: mdl-38107732
ABSTRACT

Background:

Non-genetic factors like microbial dysbiosis may be contributing to the increasing incidence/progression of type 1 diabetes mellitus (T1DM).

Objectives:

To analyse the gut microbiota profile in Indian children with T1DM and its effect on glycaemic control.

Methodology:

Faecal samples of 29 children with T1DM were collected and faecal microbial DNA was extracted and subjected to 16S rRNA (ribosomal RNA) sequencing and further analysis.

Results:

The dominant phyla in children with T1DM were Firmicutes and Bacteroidetes. Butyrate-producing bacteria Blautia and Ruminococcus showed a significant negative correlation with the glycosylated haemoglobin (HbA1C) levels (p < 0.05). Coprococcus and Propionibacterium were important negative predictors of glycaemic control (p < 0.05).

Conclusion:

Our study suggests that Indian children with T1DM have a distinct gut microbiome taxonomic composition and that short-chain fatty acid-producing bacteria like Ruminococcus and Blautia (butyrate-producing) may play an important role in the glycaemic control of subjects with T1DM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Indian J Endocrinol Metab Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: India
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Indian J Endocrinol Metab Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: India