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Total bilirubin and bilirubin-to-triglycerides ratio predict changes in glycated hemoglobin in healthy children.
Puerto-Carranza, Elsa; Nuevo-Casals, Silvia; Roca-Portella, Berta; Mas-Parés, Berta; Gómez-Vilarrubla, Ariadna; Carreras-Badosa, Gemma; Niubó, Maria; Prats-Puig, Anna; de Zegher, Francis; Ibáñez, Lourdes; Bassols, Judit; López-Bermejo, Abel.
Afiliación
  • Puerto-Carranza E; Pediatric Endocrinology Group, Girona Biomedical Research Institute (IDIBGI), Salt, Spain.
  • Nuevo-Casals S; Pediatrics, Dr. Trueta University Hospital, Girona, Spain.
  • Roca-Portella B; Pediatrics, Dr. Trueta University Hospital, Girona, Spain.
  • Mas-Parés B; Pediatrics, Dr. Trueta University Hospital, Girona, Spain.
  • Gómez-Vilarrubla A; Pediatric Endocrinology Group, Girona Biomedical Research Institute (IDIBGI), Salt, Spain.
  • Carreras-Badosa G; Maternal-Fetal Metabolic Group, Girona Biomedical Research Institute (IDIBGI), Salt, Spain.
  • Niubó M; Pediatric Endocrinology Group, Girona Biomedical Research Institute (IDIBGI), Salt, Spain.
  • Prats-Puig A; Maternal-Fetal Metabolic Group, Girona Biomedical Research Institute (IDIBGI), Salt, Spain.
  • de Zegher F; University School of Health and Sport (EUSES), University of Girona, Girona, Spain.
  • Ibáñez L; Department of Development & Regeneration, University of Leuven, Leuven, Belgium.
  • Bassols J; Endocrinology, Pediatric Research Institute, Sant Joan de Déu Children's Hospital, Esplugues, Barcelona, Spain.
  • López-Bermejo A; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), ISCIII, Madrid, Spain.
Front Endocrinol (Lausanne) ; 14: 1303597, 2023.
Article en En | MEDLINE | ID: mdl-38107514
ABSTRACT

Objective:

Bilirubin and triglycerides can regulate insulin secretion and glucose uptake. The aim of our study is to analyze associations between total bilirubin (TB) and the bilirubin-to-triglycerides ratio (BTR) with metabolic markers in healthy prepubertal children.

Methods:

Subjects were 246 healthy children (mean age 8), of whom 142 (58%) were reevaluated 4 years later (mean age 12). The subjects were stratified according to age into three groups (<7.8 years; 7.8-9.6 years; and >9.6 years; n=82 each) at baseline and into two groups (<12.9 years and ≥12.9 years; n=71 each) at follow-up. Anthropometrics and laboratory parameters [TB and its fractions (direct and indirect bilirubin), triglycerides, HDL-cholesterol, glucose, insulin, HOMA-IR, HOMA-B and glycated hemoglobin (HbA1c)] were assessed at both baseline and follow-up.

Results:

TB and BTR showed independent and negative association with baseline and follow-up HbA1c. These associations were stronger for BTR and in the highest age group. No independent associations were observed with HOMA-IR or HOMA-B.

Conclusion:

TB and BTR are independently associated with HbA1c and predict its changes over time in healthy children. Our results indicate that TB and BTR may be useful parameters in studies of glucose tolerance in healthy children.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bilirrubina / Insulina Límite: Child / Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bilirrubina / Insulina Límite: Child / Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza