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Correlation of brain iron deposition and freezing of gait in Parkinson's disease: a cross-sectional study.
Yan, Ying; Wang, Zheng; Wei, Wei; Yang, Zhenghan; Guo, Lingfei; Wang, Zhenchang; Wei, Xuan.
Afiliación
  • Yan Y; Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Wang Z; Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Wei W; Division of Science and Technology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Yang Z; Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Guo L; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
  • Wang Z; Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Wei X; Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Quant Imaging Med Surg ; 13(12): 7961-7972, 2023 Dec 01.
Article en En | MEDLINE | ID: mdl-38106290
ABSTRACT

Background:

Quantitative susceptibility mapping (QSM) is a novel imaging method for detecting iron content in the brain. The study aimed determine whether the iron deposition in the brains of people with Parkinson's disease (PD) is correlated with freezing of gait (FOG).

Methods:

We retrospectively collected the data of 24 patients with PD from the Movement Disorders Program and 36 healthy controls (HCs) from January 2021 to December 2021. Clinical assessments included mental intelligence scales, Parkinson rating scales, motor-related scales, and clinical gait assessments. All exercise scales and gait assessments were performed in the "ON" and "OFF" states. Magnetic resonance imaging (MRI) data were collected using 3-dimensional fast low-angle shot sequences. We chose the bilateral red nucleus, substantia nigra, thalamus, putamen, caudate nucleus, and globus pallidus as regions of interest for QSM analysis.

Results:

The iron deposition in the substantia nigra of the PD group was significantly higher than that of the HC group (P<0.01). In the PD group, the iron deposition in the substantia nigra of patients with FOG was significantly higher than that in patients without FOG (P=0.04). The iron deposition in the substantia nigra was positively correlated with the New Freezing of Gait Questionnaire (P=0.03). The scores for depression and anxiety of the PD group were significantly higher than those of the HC group, while the Berg balance scale score was significantly lower (P<0.01).

Conclusions:

The iron deposition in the substantia nigra of patients with PD is increased compared with that of controls and is associated with FOG. QSM can be used to detect brain iron deposition in patients with PD, which would help to explore the mechanism of abnormal neurobiological activity in FOG.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Quant Imaging Med Surg Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Quant Imaging Med Surg Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: China