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Macular blood flow changes in dysthyroid optic neuropathy after high-dose intravenous pulse methylprednisolone (IVMP).
Fan, Shu-Xian; Liang, Jia-Qi; Wang, Jing; Zhou, Chong; Zhou, Shi-You; Wang, Mei; Zeng, Peng.
Afiliación
  • Fan SX; Department of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Address: #107 West Yanjiang Road, Guangzhou 510120, People's Republic of China.
  • Liang JQ; Department of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Address: #107 West Yanjiang Road, Guangzhou 510120, People's Republic of China.
  • Wang J; Department of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Address: #107 West Yanjiang Road, Guangzhou 510120, People's Republic of China.
  • Zhou C; Department of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Address: #107 West Yanjiang Road, Guangzhou 510120, People's Republic of China.
  • Zhou SY; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, #54 South Xianlie Road, Guangzhou, Guangzhou 510060, People's Republic of China. Electronic address: zhoushiy@mail.sysu.edu.cn.
  • Wang M; Department of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Address: #107 West Yanjiang Road, Guangzhou 510120, People's Republic of China. Electronic address: wangmei2@mail.sysu.edu.cn.
  • Zeng P; Department of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Address: #107 West Yanjiang Road, Guangzhou 510120, People's Republic of China. Electronic address: zengp8@mail.sysu.edu.cn.
Photodiagnosis Photodyn Ther ; 45: 103935, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38104706
ABSTRACT

OBJECTIVE:

To investigate the changes in macular vessel density (VD) of the superficial layer of retina (SLR) and deep layer of retina (DLR) in dysthyroid optic neuropathy (DON) after high-dose intravenous pulse methylprednisolone (IVMP). MATERIALS AND

METHODS:

Eighteen DON patients (29 eyes) who completed high-dose IVMP and 16 healthy individuals (32 eyes) were enrolled in this study. Optical coherence tomography angiography (OCTA) image analysis and comprehensive ophthalmic examinations were performed, including the SLR macular whole-image VD (SLR-mwiVD) and DLR-mwiVD, best-corrected visual acuity (BCVA), the mean deviation of visual field (VF-MD), pattern standard deviation of visual field (VF-PSD) and the other parameters.

RESULTS:

The SLR-mwiVD (41.39 ± 4.71 vs. 48.13 ± 3.68, p < 0.001) and DLR-mwiVD (40.77 ± 5.85 vs. 49.14 ± 7.02, p < 0.001) were decreased in DON compared to control eyes. After IVMP, visual function parameters were improved, and SLR-mwiVD (49.41 ± 3.18, p < 0.001) and DLR-mwiVD (50.41 ± 4.04, p < 0.001) were increased in the DON group compared to pretreatment. The increased SLR-mwiVD and DLR-mwiVD were significantly correlated with improvements in BCVA (Log MAR from 0.62 ± 0.49 to -0.01 ± 0.03, p < 0.001), VF-MD (from - 6.89 ± 2.89 dB to - 1.75 ± 1.29 dB, p < 0.001) and VF-PSD (from 4.38 ± 2.52 dB to 2.32 ± 1.64 dB, p < 0.001).

CONCLUSION:

The increase in macular VD was significantly correlated with the improvement in visual function in DON after IVMP. Macular VD changes on OCTA may be a useful indicator for the response in DON after IVMP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disco Óptico / Fotoquimioterapia / Enfermedades del Nervio Óptico Límite: Humans Idioma: En Revista: Photodiagnosis Photodyn Ther Asunto de la revista: DIAGNOSTICO POR IMAGEM / TERAPEUTICA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disco Óptico / Fotoquimioterapia / Enfermedades del Nervio Óptico Límite: Humans Idioma: En Revista: Photodiagnosis Photodyn Ther Asunto de la revista: DIAGNOSTICO POR IMAGEM / TERAPEUTICA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos