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Disorganized Functional Connectivity of Anterior Insular Subnetworks in Adults with Executive Dysfunction after Trauma Exposure.
Hu, Xiao; Luo, Yifeng; Qi, Rongfeng; Ge, Jiyuan; Wu, Luoan; Dai, Huanhuan; Lan, Qingyue; Liu, Bo; Zhang, Li; Xu, Qiang; Chen, Feng; Cao, Zhihong; Lu, Guangming.
Afiliación
  • Hu X; Department of Medical Imaging, Jinling Hospital, Nanjing Medical University, Nanjing 210002, Jiangsu, China.
  • Luo Y; Department of Radiology, the Affiliated Yixing Hospital of Jiangsu University, Wuxi, China.
  • Qi R; Department of Medical Imaging, Jinling Hospital, Nanjing Medical University, Nanjing 210002, Jiangsu, China.
  • Ge J; Department of Radiology, the Affiliated Yixing Hospital of Jiangsu University, Wuxi, China.
  • Wu L; Department of Psychiatry, Yixing Mental Health Center, Wuxi, China.
  • Dai H; Department of Radiology, the Affiliated Yixing Hospital of Jiangsu University, Wuxi, China.
  • Lan Q; Department of Radiology, the Affiliated Yixing Hospital of Jiangsu University, Wuxi, China.
  • Liu B; Department of Radiology, the Affiliated Yixing Hospital of Jiangsu University, Wuxi, China.
  • Zhang L; Mental Health Institute, the Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, China.
  • Xu Q; Department of Medical Imaging, Jinling Hospital, Nanjing Medical University, Nanjing 210002, Jiangsu, China.
  • Chen F; Department of Radiology, People's Hospital of Hainan Province, Haikou 570311, China.
  • Cao Z; Department of Radiology, the Affiliated Yixing Hospital of Jiangsu University, Wuxi, China.
  • Lu G; Department of Medical Imaging, Jinling Hospital, Nanjing Medical University, Nanjing 210002, Jiangsu, China. Electronic address: cjr.luguangming@vip.163.com.
Neuroscience ; 538: 40-45, 2024 Feb 06.
Article en En | MEDLINE | ID: mdl-38103859
ABSTRACT
There is increasing evidence that major trauma can adversely affect the brain and cognition. In some cases, trauma may lead to deficits in executive function (EF). The anterior insula may be a causal outflow hub acting to coordinate EF-related brain networks. To clarify the neural underpinnings of EF deficits (EFD) after trauma, we performed a resting-state functional magnetic resonance imaging (rs-fMRI) study of anterior insular subnetworks in adults who have lost their only child. A total of 167 participants completed various psychological and cognitive assessments to assess EF-related deficits. Correlations were computed between abnormal connectivity and cognitive/post-traumatic stress symptoms. The results showed abnormal anterior insular subregion connectivity in the default mode network (DMN), prefrontal lobe, and cerebellum lobe in participants with EFD. No correlation was found between abnormal connectivity and cognitive/post-traumatic stress symptoms in participants with EFD. These results suggest that excessive connections between the insula and DMN could contribute to EFD after trauma. Overall, this study provides novel references into the neural mechanisms of EF status after trauma exposure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Disfunción Cognitiva Límite: Adult / Child / Humans Idioma: En Revista: Neuroscience Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Disfunción Cognitiva Límite: Adult / Child / Humans Idioma: En Revista: Neuroscience Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos