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Laboratory-acquired infections and pathogen escapes worldwide between 2000 and 2021: a scoping review.
Blacksell, Stuart D; Dhawan, Sandhya; Kusumoto, Marina; Le, Khanh K; Summermatter, Kathrin; O'Keefe, Joseph; Kozlovac, Joseph P; Almuhairi, Salama S; Sendow, Indrawati; Scheel, Christina M; Ahumibe, Anthony; Masuku, Zibusiso M; Bennett, Allan M; Kojima, Kazunobu; Harper, David R; Hamilton, Keith.
Afiliación
  • Blacksell SD; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Nuffield Department of Medicine Research Building, University of Oxford, Oxford, UK. Electronic addres
  • Dhawan S; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  • Kusumoto M; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  • Le KK; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  • Summermatter K; Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
  • O'Keefe J; Ministry for Primary Industries, Wellington, New Zealand.
  • Kozlovac JP; US Department of Agriculture, Agricultural Research Service, Beltsville, MD, USA.
  • Almuhairi SS; National Emergency Crisis and Disaster Management Authority, Abu Dhabi, United Arab Emirates.
  • Sendow I; Research Center for Veterinary Science, National Research and Innovation Agency, Jakarta, Indonesia.
  • Scheel CM; WHO Collaborating Center for Biosafety and Biosecurity, Office of the Associate Director for Laboratory Science, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA; Office of Science and Technology Assessment, Office of Occupational Safety and Health Administratio
  • Ahumibe A; Nigeria Centre for Disease Control and Prevention, Abuja, Nigeria.
  • Masuku ZM; National Institute for Communicable Diseases a Division of the National Health Laboratory Services, Johannesburg, South Africa.
  • Bennett AM; UK Health Security Agency, Porton Down, UK.
  • Kojima K; Department of Epidemic and Pandemic Preparedness and Prevention, WHO, Geneva, Switzerland.
  • Harper DR; The Royal Institute of International Affairs, Chatham House, London, UK.
  • Hamilton K; World Organisation for Animal Health, Paris, France.
Lancet Microbe ; 5(2): e194-e202, 2024 02.
Article en En | MEDLINE | ID: mdl-38101440
ABSTRACT
Laboratory-acquired infections (LAIs) and accidental pathogen escape from laboratory settings (APELS) are major concerns for the community. A risk-based approach for pathogen research management within a standard biosafety management framework is recommended but is challenging due to reasons such as inconsistency in risk tolerance and perception. Here, we performed a scoping review using publicly available, peer-reviewed journal and media reports of LAIs and instances of APELS between 2000 and 2021. We identified LAIs in 309 individuals in 94 reports for 51 pathogens. Eight fatalities (2·6% of all LAIs) were caused by infection with Neisseria meningitidis (n=3, 37·5%), Yersinia pestis (n=2, 25%), Salmonella enterica serotype Typhimurium (S Typhimurium; n=1, 12·5%), or Ebola virus (n=1, 12·5%) or were due to bovine spongiform encephalopathy (n=1, 12·5%). The top five LAI pathogens were S Typhimurium (n=154, 49·8%), Salmonella enteritidis (n=21, 6·8%), vaccinia virus (n=13, 4·2%), Brucella spp (n=12, 3·9%), and Brucella melitensis (n=11, 3·6%). 16 APELS were reported, including those for Bacillus anthracis, SARS-CoV, and poliovirus (n=3 each, 18·8%); Brucella spp and foot and mouth disease virus (n=2 each, 12·5%); and variola virus, Burkholderia pseudomallei, and influenza virus H5N1 (n=1 each, 6·3%). Continual improvement in LAI and APELS management via their root cause analysis and thorough investigation of such incidents is essential to prevent future occurrences. The results are biased due to the reliance on publicly available information, which emphasises the need for formalised global LAIs and APELS reporting to better understand the frequency of and circumstances surrounding these incidents.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Yersinia pestis / Subtipo H5N1 del Virus de la Influenza A / Infección de Laboratorio Tipo de estudio: Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Lancet Microbe Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Yersinia pestis / Subtipo H5N1 del Virus de la Influenza A / Infección de Laboratorio Tipo de estudio: Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Lancet Microbe Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido