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Platelet membrane-derived biomimetic microbubbles with enhanced targeting ability for the early detection of myocardial ischemia-reperfusion injury.
Bai, Ying; Chen, Yihan; Jin, Qiaofeng; Deng, Cheng; Xu, Lingling; Huang, Tian; He, Shukun; Fu, Yanan; Qiu, Jiani; Xu, Jia; Gao, Tang; Wu, Wenqian; Lv, Qing; Yang, Yali; Zhang, Li; Xie, Mingxing; Dong, Xiaoqiu; Wang, Jing.
Afiliación
  • Bai Y; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
  • Chen Y; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China; Department of Ultras
  • Jin Q; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
  • Deng C; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
  • Xu L; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
  • Huang T; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
  • He S; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
  • Fu Y; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
  • Qiu J; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
  • Xu J; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
  • Gao T; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
  • Wu W; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
  • Lv Q; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
  • Yang Y; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
  • Zhang L; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China; Shenzhen Huazhong Un
  • Xie M; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China; Shenzhen Huazhong Un
  • Dong X; Department of Ultrasonography, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: dongxq0451@163.com.
  • Wang J; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Clinical Research Center for Medical Imaging in Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China. Electronic address:
Colloids Surf B Biointerfaces ; 234: 113680, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38101143
ABSTRACT
Myocardial ischemia-reperfusion injury (MIRI) is a widely recognized cardiovascular disease that significantly impacts the prognosis of patients undergoing myocardial infarction recanalization. This condition can be fatal and involves complex pathophysiological mechanisms. Early diagnosis of MIRI is crucial to minimize myocardial damage and reducing mortality. Based on the inherent relationship between platelets and MIRI, we developed biomimetic microbubbles coated with platelet membrane (MB-pla) for early identification of MIRI. The MB-pla were prepared through a recombination process involving platelet membrane obtained from rat whole blood and phospholipids, blended in appropriate proportions. By coating the microbubbles with platelet membrane, MB-pla acquired various adhesion molecules, thereby gaining the capability to selectively adhere to damaged endothelial cells in the context of MIRI. In vitro experiments demonstrated that MB-pla exhibited remarkable targeting characteristics, particularly toward type IV collagen and human umbilical vein endothelial cells that had been injured through hypoxia/reoxygenation procedures. In a rat model of MIRI, the signal intensity produced by MB-pla was notably higher than that of control microbubbles. These findings were consistent with results obtained from fluorescence imaging of isolated hearts and immunofluorescence staining of tissue sections. In conclusion, MB-pla has great potential as a non-invasive early detection method for MIRI. Furthermore, this approach can potentially find application in other conditions involving endothelial injury in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión Miocárdica Límite: Animals / Humans Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión Miocárdica Límite: Animals / Humans Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos