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HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function.
Friedman, Clayton E; Cheetham, Seth W; Negi, Sumedha; Mills, Richard J; Ogawa, Masahito; Redd, Meredith A; Chiu, Han Sheng; Shen, Sophie; Sun, Yuliangzi; Mizikovsky, Dalia; Bouveret, Romaric; Chen, Xiaoli; Voges, Holly K; Paterson, Scott; De Angelis, Jessica E; Andersen, Stacey B; Cao, Yuanzhao; Wu, Yang; Jafrani, Yohaann M A; Yoon, Sohye; Faulkner, Geoffrey J; Smith, Kelly A; Porrello, Enzo; Harvey, Richard P; Hogan, Benjamin M; Nguyen, Quan; Zeng, Jian; Kikuchi, Kazu; Hudson, James E; Palpant, Nathan J.
Afiliación
  • Friedman CE; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Cheetham SW; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Negi S; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Mills RJ; QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia; School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia; Novo Nordisk Foundation Center for Stem Cell Medicine, Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia; Departme
  • Ogawa M; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia; School of Clinical Medicine and School of Biotechnology and Biomolecular Science, UNSW Sydney, Kensington, Sydney, NSW 2052, Australia.
  • Redd MA; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Chiu HS; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Shen S; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Sun Y; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Mizikovsky D; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Bouveret R; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia; School of Clinical Medicine and School of Biotechnology and Biomolecular Science, UNSW Sydney, Kensington, Sydney, NSW 2052, Australia.
  • Chen X; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Voges HK; QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia; School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia.
  • Paterson S; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • De Angelis JE; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Andersen SB; Genome Innovation Hub, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Cao Y; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Wu Y; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Jafrani YMA; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Yoon S; Genome Innovation Hub, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Faulkner GJ; Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia; Mater Research Institute, University of Queensland, Woolloongabba, QLD 4102, Australia.
  • Smith KA; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Porrello E; Novo Nordisk Foundation Center for Stem Cell Medicine, Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine, The Royal Children's Hospital, Melbourne, VIC 3052, Australia; Department of Anatomy and Physiology, S
  • Harvey RP; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia; School of Clinical Medicine and School of Biotechnology and Biomolecular Science, UNSW Sydney, Kensington, Sydney, NSW 2052, Australia.
  • Hogan BM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Nguyen Q; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Zeng J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Kikuchi K; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia; School of Clinical Medicine and School of Biotechnology and Biomolecular Science, UNSW Sydney, Kensington, Sydney, NSW 2052, Australia.
  • Hudson JE; QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia; School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia; School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
  • Palpant NJ; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: n.palpant@uq.edu.au.
Dev Cell ; 59(1): 91-107.e6, 2024 Jan 08.
Article en En | MEDLINE | ID: mdl-38091997
Genomic regulation of cardiomyocyte differentiation is central to heart development and function. This study uses genetic loss-of-function human-induced pluripotent stem cell-derived cardiomyocytes to evaluate the genomic regulatory basis of the non-DNA-binding homeodomain protein HOPX. We show that HOPX interacts with and controls cardiac genes and enhancer networks associated with diverse aspects of heart development. Using perturbation studies in vitro, we define how upstream cell growth and proliferation control HOPX transcription to regulate cardiac gene programs. We then use cell, organoid, and zebrafish regeneration models to demonstrate that HOPX-regulated gene programs control cardiomyocyte function in development and disease. Collectively, this study mechanistically links cell signaling pathways as upstream regulators of HOPX transcription to control gene programs underpinning cardiomyocyte identity and function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miocitos Cardíacos / Células Madre Pluripotentes Inducidas Límite: Animals / Humans Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miocitos Cardíacos / Células Madre Pluripotentes Inducidas Límite: Animals / Humans Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos