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Saccharomyces cerevisiae biofactory to produce naringenin using a systems biology approach and a bicistronic vector expression strategy in flavonoid production.
Mejía-Manzano, Luis Alberto; Ortiz-Alcaráz, César Iván; Parra Daza, Laura E; Suarez Medina, Lina; Vargas-Cortez, Teresa; Fernández-Niño, Miguel; González Barrios, Andrés Fernando; González-Valdez, José.
Afiliación
  • Mejía-Manzano LA; School of Engineering and Science, Tecnologico de Monterrey , Monterrey, Nuevo León, Mexico.
  • Ortiz-Alcaráz CI; School of Engineering and Science, Tecnologico de Monterrey , Monterrey, Nuevo León, Mexico.
  • Parra Daza LE; School of Engineering and Science, Tecnologico de Monterrey , Monterrey, Nuevo León, Mexico.
  • Suarez Medina L; Department of Chemical and Food Engineering, Grupo de Diseño de Productos y Procesos (GDPP), Universidad de los Andes , Bogotá, Colombia.
  • Vargas-Cortez T; Department of Chemical and Food Engineering, Grupo de Diseño de Productos y Procesos (GDPP), Universidad de los Andes , Bogotá, Colombia.
  • Fernández-Niño M; School of Engineering and Science, Tecnologico de Monterrey , Monterrey, Nuevo León, Mexico.
  • González Barrios AF; Department of Chemical and Food Engineering, Grupo de Diseño de Productos y Procesos (GDPP), Universidad de los Andes , Bogotá, Colombia.
  • González-Valdez J; Department of Bioorganic Chemistry, Leibniz-Institute of Plant Biochemistry , Halle, Germany.
Microbiol Spectr ; 12(1): e0337423, 2024 Jan 11.
Article en En | MEDLINE | ID: mdl-38088543
IMPORTANCE: Flavonoids are a group of compounds generally produced by plants with proven biological activity, which have recently beeen recommended for the treatment and prevention of diseases and ailments with diverse causes. In this study, naringenin was produced in adequate amounts in yeast after in silico design. The four genes of the involved enzymes from several organisms (bacteria and plants) were multi-expressed in two vectors carrying each two genes linked by a short viral peptide sequence. The batch kinetic behavior of the product, substrate, and biomass was described at lab scale. The engineered strain might be used in a more affordable and viable bioprocess for industrial naringenin procurement.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Flavanonas Idioma: En Revista: Microbiol Spectr Año: 2024 Tipo del documento: Article País de afiliación: México Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Flavanonas Idioma: En Revista: Microbiol Spectr Año: 2024 Tipo del documento: Article País de afiliación: México Pais de publicación: Estados Unidos