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Longitudinal development of the human white matter structural connectome and its association with brain transcriptomic and cellular architecture.
Feng, Guozheng; Chen, Rui; Zhao, Rui; Li, Yuanyuan; Ma, Leilei; Wang, Yanpei; Men, Weiwei; Gao, Jiahong; Tan, Shuping; Cheng, Jian; He, Yong; Qin, Shaozheng; Dong, Qi; Tao, Sha; Shu, Ni.
Afiliación
  • Feng G; State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
  • Chen R; BABRI Centre, Beijing Normal University, Beijing, China.
  • Zhao R; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China.
  • Li Y; State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
  • Ma L; College of Life Sciences, Beijing Normal University, Beijing, China.
  • Wang Y; Beijing Key Laboratory of Gene Resource and Molecular Development, Beijing, China.
  • Men W; State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
  • Gao J; State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
  • Tan S; State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
  • Cheng J; Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
  • He Y; Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
  • Qin S; Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, China.
  • Dong Q; School of Computer Science and Engineering, Beihang University, Beijing, China.
  • Tao S; State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
  • Shu N; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China.
Commun Biol ; 6(1): 1257, 2023 12 12.
Article en En | MEDLINE | ID: mdl-38087047
From childhood to adolescence, the spatiotemporal development pattern of the human brain white matter connectome and its underlying transcriptomic and cellular mechanisms remain largely unknown. With a longitudinal diffusion MRI cohort of 604 participants, we map the developmental trajectory of the white matter connectome from global to regional levels and identify that most brain network properties followed a linear developmental trajectory. Importantly, connectome-transcriptomic analysis reveals that the spatial development pattern of white matter connectome is potentially regulated by the transcriptomic architecture, with positively correlated genes involve in ion transport- and development-related pathways expressed in excitatory and inhibitory neurons, and negatively correlated genes enriches in synapse- and development-related pathways expressed in astrocytes, inhibitory neurons and microglia. Additionally, the macroscale developmental pattern is also associated with myelin content and thicknesses of specific laminas. These findings offer insights into the underlying genetics and neural mechanisms of macroscale white matter connectome development from childhood to adolescence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conectoma / Sustancia Blanca Límite: Adolescent / Child / Humans Idioma: En Revista: Commun Biol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conectoma / Sustancia Blanca Límite: Adolescent / Child / Humans Idioma: En Revista: Commun Biol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido