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Flow-based basophil activation test in immediate drug hypersensitivity. An EAACI task force position paper.
Mayorga, C; Çelik, G E; Pascal, M; Hoffmann, H J; Eberlein, B; Torres, M J; Brockow, K; Garvey, L H; Barbaud, A; Madrigal-Burgaleta, R; Caubet, J C; Ebo, D G.
Afiliación
  • Mayorga C; Allergy Unit, Hospital Regional Universitario de Málaga and Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain.
  • Çelik GE; RETICS Asma reacciones adversas y alérgicas (ARADYAL) and RICORS Red De Enfermedades Inflamatorias (REI), Madrid, Spain.
  • Pascal M; Department of chest disease, Division of Allergy & Immunology, Ankara University School of Medicine, Ankara, Turkey.
  • Hoffmann HJ; RETICS Asma reacciones adversas y alérgicas (ARADYAL) and RICORS Red De Enfermedades Inflamatorias (REI), Madrid, Spain.
  • Eberlein B; Immunology Department, Centre de Diagnòstic Biomèdic, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Torres MJ; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain.
  • Brockow K; Department of Clinical Medicine and Department of Clinical Immunology, Aarhus University and Aarhus University Hospital, Aarhus N, Denmark.
  • Garvey LH; Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University Munich, Munich, Germany.
  • Barbaud A; Allergy Unit, Hospital Regional Universitario de Málaga and Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain.
  • Madrigal-Burgaleta R; RETICS Asma reacciones adversas y alérgicas (ARADYAL) and RICORS Red De Enfermedades Inflamatorias (REI), Madrid, Spain.
  • Caubet JC; Medicine Department, Malaga University, Málaga, Spain.
  • Ebo DG; Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University Munich, Munich, Germany.
Allergy ; 79(3): 580-600, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38084472
Diagnosing immediate drug hypersensitivity reactions (IDHRs) can pose a significant challenge and there is an urgent need for safe and reliable tests. Evidence has emerged that the basophil activation test (BAT), an in vitro assay that mirrors the in vivo response, can be a complementary test for many drugs. In this position paper, members of Task Force (TF) "Basophil activation test in the evaluation of Drug Hypersensitivity Reactions" from the European Academy of Allergy and Clinical Immunology (EAACI) present the data from a survey about the use and utility of BAT in IDHRs in Europe. The survey results indicate that there is a great interest for using BAT especially for diagnosing IDHRs. However, there are still main needs, mainly in the standardization of the protocols. Subsequently consensus-based recommendations were formulated for: (i) Technical aspects of BAT in IDHRs including type of sample, management of drugs, flow cytometry protocols, interpretation of the results; and (ii) Drug-specific aspects that should be taken into account when performing BAT in relation to betalactams, neuromuscular blocking agents, fluoroquinolones, chlorhexidine, opioids, radio contrast media, chemotherapeutics, biological agents, nonsteroidal anti-inflammatory drugs, COVID vaccine, and excipients. Moreover, aspects in the evaluation of pediatric population have also been considered. All this indicates that BAT offers the clinician and laboratory a complementary tool for a safe diagnostic for IDHRs, although its place in the diagnostic algorithm depends on the drug class and patient population (phenotype, geography, and age). The standardization of BAT is important for generalizing this method beyond the individual laboratory.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipersensibilidad a las Drogas / Hipersensibilidad / Hipersensibilidad Inmediata Límite: Child / Humans Idioma: En Revista: Allergy Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Dinamarca
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipersensibilidad a las Drogas / Hipersensibilidad / Hipersensibilidad Inmediata Límite: Child / Humans Idioma: En Revista: Allergy Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Dinamarca