Your browser doesn't support javascript.
loading
Dementia and mortality in older adults: A twin study.
Jang, Jung Yun; Beam, Christopher R; Karlsson, Ida K; Pedersen, Nancy L; Gatz, Margaret.
Afiliación
  • Jang JY; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, USA.
  • Beam CR; Department of Psychology, University of Southern California, Los Angeles, California, USA.
  • Karlsson IK; Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
  • Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Gatz M; Department of Psychology, University of Southern California, Los Angeles, California, USA.
Alzheimers Dement ; 20(3): 1682-1692, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38078564
INTRODUCTION: Dementia predicts increased mortality. We used case-control and co-twin control models to investigate genetic and shared environmental influences on this association. METHODS: Case-control design, including 987 twins with dementia and 2938 age- and sex-matched controls in the Swedish Twin Registry. Co-twin control design, including 90 monozygotic (MZ) and 288 dizygotic (DZ) twin pairs discordant for dementia. To test for genetic and environmental confounding, differences were examined in mortality risk between twins with dementia and their matched or co-twin controls. RESULTS: Twins with dementia showed greater mortality risk than age- and sex-matched controls (HR = 2.02 [1.86, 2.18]). Mortality risk is significantly elevated but attenuated substantially in discordant twin pairs, for example, comparing MZ twins with dementia to their co-twin controls (HR = 1.48 [1.08, 2.04]). DISCUSSION: Findings suggest that genetic factors partially confound the association between dementia and mortality and provide an alternative hypothesis to increased mortality due to dementia itself. Highlights We studied dementia and mortality in twin pairs discordant for dementia. People without dementia outlived people with dementia. Identical twins with dementia and their co-twin controls had similar survival time. Findings suggest genotype may explain the link between dementia and mortality.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gemelos Monocigóticos / Demencia Límite: Aged / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gemelos Monocigóticos / Demencia Límite: Aged / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos