Biological studies of clavine alkaloids targeting CNS receptors.

Tasker, Nikhil R; Pazur, Ethan J; Wipf, Peter

Tasker, Nikhil R; Pazur, Ethan J; Wipf, Peter.

Afiliación

Tasker NR; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, United States.
Pazur EJ; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, United States.
Wipf P; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, United States.

Front Psychiatry ; 14: 1286941, 2023.

Article en En | MEDLINE | ID: mdl-38076698

RESUMEN

In contrast to well established psychedelics such as lysergic acid diethylamide (LSD) and psilocybin, ergot alkaloids of the clavine subclass have not been thoroughly investigated, in spite of their broad occurrence in nature and their well-established potent physiological effects. This study presents the current knowledge on the biological properties of clavine alkaloids, draws comparisons to the pharmacology of ergolines and related psychedelics, and demonstrates opportunities to develop novel structure-activity relationship (SAR) profiles. The latter could usher in a new stage of medicinal chemistry studies that enable an expansion of the currently structurally limited portfolio of psychedelic therapeutics.

Palabras clave

agroclavine; anxiety; cycloclavine; depression; ergot alkaloids; lysergol; neuropsychiatric diseases; psychedelic therapies

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Psychiatry Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza

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