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Role of solute carrier transporters in regulating dendritic cell maturation and function.
Shao, Lin; Yang, Mengxin; Sun, Tao; Xia, Haotang; Du, Dan; Li, Xun; Jie, Zuliang.
Afiliación
  • Shao L; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
  • Yang M; School of Life Sciences, Fudan University, Shanghai, China.
  • Sun T; School of Public Health, Xiamen University, Xiamen, Fujian, China.
  • Xia H; Department of Laboratory Medicine, The First Affiliated Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
  • Du D; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
  • Li X; Department of Stomatology, School of Medicine, Xiamen University, Xiamen, Fujian, China.
  • Jie Z; Cancer Research Center, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Eur J Immunol ; 54(2): e2350385, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38073515
Dendritic cells (DCs) are specialized antigen-presenting cells that initiate and regulate innate and adaptive immune responses. Solute carrier (SLC) transporters mediate diverse physiological functions and maintain cellular metabolite homeostasis. Recent studies have highlighted the significance of SLCs in immune processes. Notably, upon activation, immune cells undergo rapid and robust metabolic reprogramming, largely dependent on SLCs to modulate diverse immunological responses. In this review, we explore the central roles of SLC proteins and their transported substrates in shaping DC functions. We provide a comprehensive overview of recent studies on amino acid transporters, metal ion transporters, and glucose transporters, emphasizing their essential contributions to DC homeostasis under varying pathological conditions. Finally, we propose potential strategies for targeting SLCs in DCs to bolster immunotherapy for a spectrum of human diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Transporte de Membrana / Proteínas Transportadoras de Solutos Límite: Humans Idioma: En Revista: Eur J Immunol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Transporte de Membrana / Proteínas Transportadoras de Solutos Límite: Humans Idioma: En Revista: Eur J Immunol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania