A novel liquid chromatography with quadrupole time-of-flight-tandem mass spectroscopy method for ultra-trace level identification and quantification of the genotoxic impurity 2,6-diamino-5-nitropyrimidin-4(3H)-one in valganciclovir hydrochloride.

Ali, Shaik Mahammad; Moorthy, Manchuri Krishna; Devanna, Nayakanti

Ali, Shaik Mahammad; Moorthy, Manchuri Krishna; Devanna, Nayakanti.

Afiliación

Ali SM; Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India.
Moorthy MK; Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India.
Devanna N; Department of Chemistry, JNTUA College of Engineering, Kalikiri, Annamayya District, Andhra Pradesh, India.

Biomed Chromatogr ; 38(3): e5805, 2024 Mar.

Article en En | MEDLINE | ID: mdl-38072000

Asunto(s)

Daño del ADN; Espectrometría de Masas en Tándem; Valganciclovir; Cromatografía Liquida; Guanina; Cromatografía Líquida de Alta Presión

Palabras clave

2,6-diamino-5-nitropyrimidin-4(3H)-one (DMNP); fragmentation; liquid chromatography-quadrupole time-of-flight-tandem mass spectroscopy (LC-QTOF-MS/MS); ultra-trace level quantification; valganciclovir hydrochloride (VAL) genotoxic impurity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Espectrometría de Masas en Tándem Idioma: En Revista: Biomed Chromatogr Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

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