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RNA m6A methylation and MDSCs: Roles and therapeutic implications for radiotherapy.
Wang, Liangliang; Katipally, Rohan R; Liang, Hua Laura; Yang, Kaiting; Pitroda, Sean P; He, Chuan; Weichselbaum, Ralph R.
Afiliación
  • Wang L; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA; Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL 60637, USA. Electronic address: wangliang@uchicago.edu.
  • Katipally RR; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.
  • Liang HL; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA; Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL 60637, USA.
  • Yang K; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA; Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL 60637, USA.
  • Pitroda SP; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA; Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL 60637, USA.
  • He C; Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA; Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA.
  • Weichselbaum RR; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA; Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL 60637, USA. Electronic address: rweichselbaum@bsd.uchicago.edu.
Med ; 4(12): 863-874, 2023 Dec 08.
Article en En | MEDLINE | ID: mdl-38070481
Emerging evidence suggests that local tumor radiotherapy reshapes the repertoire of circulating myeloid-derived suppressor cells (MDSCs) and leads to their infiltration into the tumor microenvironment, which poses a major obstacle for radiotherapy efficacy. Recent findings have identified RNA m6A modification at the nexus of both anti-tumor immunity and radiation response. Here, we examine the mechanisms by which this RNA modification modulates the immune milieu of the radiation-remodeled tumor microenvironment. We discuss potential therapeutic interventions targeting m6A machinery to improve radiotherapy response.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Supresoras de Origen Mieloide / Neoplasias Límite: Humans Idioma: En Revista: Med Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Supresoras de Origen Mieloide / Neoplasias Límite: Humans Idioma: En Revista: Med Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos