PSPC1 Inhibition Synergizes with Poly(ADP-ribose) Polymerase Inhibitors in a Preclinical Model of BRCA-Mutated Breast/Ovarian Cancer.

Ghosh, Mithun; Kang, Min Sil; Katuwal, Nar Bahadur; Hong, Sa Deok; Jeong, Yeong Gyu; Park, Seong Min; Kim, Seul-Gi; Moon, Yong Wha

Ghosh, Mithun; Kang, Min Sil; Katuwal, Nar Bahadur; Hong, Sa Deok; Jeong, Yeong Gyu; Park, Seong Min; Kim, Seul-Gi; Moon, Yong Wha.

Afiliación

Ghosh M; Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea.
Kang MS; Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea.
Katuwal NB; Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea.
Hong SD; Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea.
Jeong YG; Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea.
Park SM; Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea.
Kim SG; Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea.
Moon YW; Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea.

Int J Mol Sci ; 24(23)2023 Dec 03.

Article en En | MEDLINE | ID: mdl-38069409

Asunto(s)

Antineoplásicos; Neoplasias de la Mama; Neoplasias Ováricas; Inhibidores de Poli(ADP-Ribosa) Polimerasas; Animales; Antineoplásicos/uso terapéutico; Inhibidores de Poli(ADP-Ribosa) Polimerasas/uso terapéutico; Neoplasias Ováricas/tratamiento farmacológico; Humanos; Femenino; Ratones; Neoplasias de la Mama/tratamiento farmacológico; Línea Celular Tumoral; Proteínas de Unión al ARN/antagonistas & inhibidores; Proteína BRCA1/genética; Proteína BRCA2/genética; ARN Interferente Pequeño/genética

Palabras clave

DNA double-strand break; PARP inhibitor; PSPC1; sensitivity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias de la Mama / Inhibidores de Poli(ADP-Ribosa) Polimerasas / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article Pais de publicación: Suiza

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