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Trehalose and Dry Eye Disease: A Comprehensive Systematic Review of Randomized Controlled Trials.
Ballesteros-Sánchez, Antonio; Martinez-Perez, Clara; Alvarez-Peregrina, Cristina; Sánchez-Tena, Miguel Ángel; De-Hita-Cantalejo, Concepción; Sánchez-González, María Carmen; Sánchez-González, José-María.
Afiliación
  • Ballesteros-Sánchez A; Department of Physics of Condensed Matter, Optics Area, University of Seville, 41004 Seville, Spain.
  • Martinez-Perez C; Department of Ophthalmology, Clínica Novovisión, 30008 Murcia, Spain.
  • Alvarez-Peregrina C; ISEC LISBOA (Instituto Superior de Educação e Ciências), 1750-142 Lisbon, Portugal.
  • Sánchez-Tena MÁ; Optometry and Vision Department, Faculty of Optics and Optometry, Complutense University of Madrid, 28037 Madrid, Spain.
  • De-Hita-Cantalejo C; Optometry and Vision Department, Faculty of Optics and Optometry, Complutense University of Madrid, 28037 Madrid, Spain.
  • Sánchez-González MC; Department of Physics of Condensed Matter, Optics Area, University of Seville, 41004 Seville, Spain.
  • Sánchez-González JM; Department of Physics of Condensed Matter, Optics Area, University of Seville, 41004 Seville, Spain.
J Clin Med ; 12(23)2023 Nov 25.
Article en En | MEDLINE | ID: mdl-38068353
The purpose of the research project was to extensively review the efficacy and safety of a trehalose tear-substitute treatment in cases of dry eye disease (DED). A systematic review that included only full-length randomized controlled studies (RCTs) reporting the effects of trehalose tear-substitute treatment in three databases, PubMed, Scopus and Web of Science, was performed according to the PRISMA statement. The search period included papers published before 8 August 2023. The Cochrane risk-of-bias tool was used to analyze the quality of the studies selected. A total of 10 RCTs were included in this systematic review. Trehalose tear-substitute treatments achieved a higher improvement than did control group interventions in all reported variables. The mean differences between both groups were in favor of trehalose, and were as follows: ocular surface disease index (OSDI) questionnaire score of -8.5 ± 7 points, tear film breakup time (TBUT) of 1.9 ± 1 s, tear film thickness (TFT) of 0.25 ± 0.1 µm, tear meniscus height (TMH) of 0.02 ± 0.02 mm, Schirmer test (ST) of 0.8 ± 1.4 mm, corneal fluorescein staining (CFS) of -0.7 ± 0.1 points and visual acuity (VA) of 0.3 ± 2.1 letters. No adverse events after trehalose tear-substitute treatments were reported. Trehalose tear substitutes are a safe and effective treatment for DED. Therefore, trehalose tear substitutes should be recommended for patients with dry eye disease. In addition, there is specific evidence to support its use in the preoperative cataract surgery period.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Systematic_reviews Idioma: En Revista: J Clin Med Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Systematic_reviews Idioma: En Revista: J Clin Med Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza