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Clinical characteristics, treatment, and outcome of patients with large cell neuroendocrine carcinoma of the lung and brain metastases - data from a tertiary care center.
Popov, Petar; Steindl, Ariane; Wolff, Ladislaia; Bergen, Elisabeth S; Eckert, Franziska; Frischer, Josa M; Widhalm, Georg; Fuereder, Thorsten; Raderer, Markus; Berghoff, Anna S; Preusser, Matthias; Kiesewetter, Barbara.
Afiliación
  • Popov P; Department of Medicine I, Division of Oncology, Medical University of Vienna, Waehringer Guertel 18 - 20, Vienna, A-1090, Austria.
  • Steindl A; Department of Medicine I, Division of Oncology, Medical University of Vienna, Waehringer Guertel 18 - 20, Vienna, A-1090, Austria.
  • Wolff L; Department of Medicine I, Division of Oncology, Medical University of Vienna, Waehringer Guertel 18 - 20, Vienna, A-1090, Austria.
  • Bergen ES; Department of Medicine I, Division of Oncology, Medical University of Vienna, Waehringer Guertel 18 - 20, Vienna, A-1090, Austria.
  • Eckert F; Department of Radiation Oncology, Medical University of Vienna, Vienna, Austria.
  • Frischer JM; Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.
  • Widhalm G; Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.
  • Fuereder T; Department of Medicine I, Division of Oncology, Medical University of Vienna, Waehringer Guertel 18 - 20, Vienna, A-1090, Austria.
  • Raderer M; Department of Medicine I, Division of Oncology, Medical University of Vienna, Waehringer Guertel 18 - 20, Vienna, A-1090, Austria.
  • Berghoff AS; Department of Medicine I, Division of Oncology, Medical University of Vienna, Waehringer Guertel 18 - 20, Vienna, A-1090, Austria.
  • Preusser M; Department of Medicine I, Division of Oncology, Medical University of Vienna, Waehringer Guertel 18 - 20, Vienna, A-1090, Austria.
  • Kiesewetter B; Department of Medicine I, Division of Oncology, Medical University of Vienna, Waehringer Guertel 18 - 20, Vienna, A-1090, Austria. barbara.kiesewetter@meduniwien.ac.at.
Clin Exp Metastasis ; 41(1): 25-32, 2024 02.
Article en En | MEDLINE | ID: mdl-38064128
Large cell neuroendocrine carcinoma (LCNEC) of the lung is an aggressive malignancy, with brain metastases (BM) occurring in approximately 20% of cases. There are currently no therapy guidelines for this population as only few data on the management of LCNEC and BM have been published. For this retrospective single center study, patients with LCNEC and BM were identified from the Vienna Brain Metastasis Registry. Data on clinicopathological features, BM-specific characteristics, treatment, and outcome were extracted. In total, 52/6083 (0.09%) patients in the dataset had a diagnosis of LCNEC and radiologically verified BM. Median age at diagnosis of LCNEC and BM was 59.1 and 60.1 years, respectively. Twenty-seven (51.9%) presented with single BM, while 12 (23%) exhibited > 3 BM initially. Neurologic symptoms due to BM were present in n = 40 (76.9%), encompassing neurologic deficits (n = 24), increased intracranial pressure (n = 18), and seizures (n = 6). Initial treatment of BM was resection (n = 13), whole brain radiation therapy (n = 19), and/or stereotactic radiosurgery (n = 25). Median overall survival (mOS) from LCNEC diagnosis was 16 months, and mOS after BM diagnosis was 7 months. Patients with synchronous BM had reduced mOS from LCNEC diagnosis versus patients with metachronous BM (11 versus 27 months, p = 0.003). Median OS after BM diagnosis did not differ between LCNEC patients and a control group of small cell lung cancer patients with BM (7 versus 6 months, p = 0.17). Patients with LCNEC and BM have a poor prognosis, particularly when synchronous BM are present. Prospective trials are required to define optimal therapeutic algorithms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Carcinoma Neuroendocrino / Carcinoma de Células Grandes / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Clin Exp Metastasis Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Carcinoma Neuroendocrino / Carcinoma de Células Grandes / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Clin Exp Metastasis Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Países Bajos