Targeted therapies for lupus nephritis: Current perspectives and future directions.
Chin Med J (Engl)
; 137(1): 34-43, 2024 Jan 05.
Article
en En
| MEDLINE
| ID: mdl-38057972
ABSTRACT: Lupus nephritis (LN), a severe manifestation of systemic lupus erythematosus, poses a substantial risk of progression to end-stage renal disease, with increased mortality. Conventional therapy for LN relies on broad-spectrum immunosuppressants such as glucocorticoids, mycophenolate mofetil, and calcineurin inhibitors. Although therapeutic regimens have evolved over the years, they have inherent limitations, including non-specific targeting, substantial adverse effects, high relapse rates, and prolonged maintenance and remission courses. These drawbacks underscore the need for targeted therapeutic strategies for LN. Recent advancements in our understanding of LN pathogenesis have led to the identification of novel therapeutic targets and the emergence of biological agents and small-molecule inhibitors with improved specificity and reduced toxicity. This review provides an overview of the current evidence on targeted therapies for LN, elucidates the biological mechanisms of responses and failure, highlights the challenges ahead, and outlines strategies for subsequent clinical trials and integrated immunomodulatory approaches.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nefritis Lúpica
/
Lupus Eritematoso Sistémico
Límite:
Humans
Idioma:
En
Revista:
Chin Med J (Engl)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China