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Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth.
Kschonsak, Yvonne T; Gao, Xinxin; Miller, Stephen E; Hwang, Sunhee; Marei, Hadir; Wu, Ping; Li, Yanjie; Ruiz, Karen; Dorighi, Kristel; Holokai, Loryn; Perampalam, Pirunthan; Tsai, Wen-Ting K; Kee, Yee-Seir; Agard, Nicholas J; Harris, Seth F; Hannoush, Rami N; de Sousa E Melo, Felipe.
Afiliación
  • Kschonsak YT; Department of Discovery Oncology, Genentech Inc, South San Francisco, CA 94080, USA. Electronic address: kschonsy@gene.com.
  • Gao X; Department of Early Discovery Biochemistry and Peptide Therapeutics, Genentech Inc, South San Francisco, CA 94080, USA. Electronic address: gaox7@gene.com.
  • Miller SE; Department of Early Discovery Biochemistry and Peptide Therapeutics, Genentech Inc, South San Francisco, CA 94080, USA.
  • Hwang S; Department of Early Discovery Biochemistry and Peptide Therapeutics, Genentech Inc, South San Francisco, CA 94080, USA.
  • Marei H; Department of Discovery Oncology, Genentech Inc, South San Francisco, CA 94080, USA.
  • Wu P; Department of Structural Biology, Genentech Inc, South San Francisco, CA 94080, USA.
  • Li Y; Department of Early Discovery Biochemistry and Peptide Therapeutics, Genentech Inc, South San Francisco, CA 94080, USA.
  • Ruiz K; Department of Discovery Oncology, Genentech Inc, South San Francisco, CA 94080, USA.
  • Dorighi K; Department of Molecular Biology, Genentech Inc, South San Francisco, CA 94080, USA.
  • Holokai L; Department of Biomarker Discovery, Genentech Inc, South San Francisco, CA 94080, USA.
  • Perampalam P; ProCogia Inc. under contract to Hoffmann-La Roche Limited, Toronto, Ontario M5J2P1, Canada.
  • Tsai WK; Department of Antibody Engineering, Genentech Inc, South San Francisco, CA 94080, USA.
  • Kee YS; Department of Antibody Engineering, Genentech Inc, South San Francisco, CA 94080, USA.
  • Agard NJ; Department of Antibody Engineering, Genentech Inc, South San Francisco, CA 94080, USA.
  • Harris SF; Department of Structural Biology, Genentech Inc, South San Francisco, CA 94080, USA.
  • Hannoush RN; Department of Early Discovery Biochemistry and Peptide Therapeutics, Genentech Inc, South San Francisco, CA 94080, USA. Electronic address: ramihannoush@gmail.com.
  • de Sousa E Melo F; Department of Discovery Oncology, Genentech Inc, South San Francisco, CA 94080, USA. Electronic address: desousaf@gene.com.
Cell Chem Biol ; 2023 Dec 05.
Article en En | MEDLINE | ID: mdl-38056465
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cell Chem Biol Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cell Chem Biol Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos