Sterically demanding Csp2(ortho-substitution)-Csp3(tertiary) bond formation via carboxylate-directed Mizoroki-Heck reaction under extra-ligand-free conditions.

Zeng, Wei; Chen, Ai-Wen; Yan, Ming-Jie; Wang, Jie

Sterically demanding Csp²(ortho-substitution)-Csp³(tertiary) bond formation via carboxylate-directed Mizoroki-Heck reaction under extra-ligand-free conditions.

Zeng, Wei; Chen, Ai-Wen; Yan, Ming-Jie; Wang, Jie.

Afiliación

Zeng W; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China. jiewang@simm.ac.cn.
Chen AW; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Yan MJ; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China. jiewang@simm.ac.cn.
Wang J; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Org Biomol Chem ; 22(1): 80-84, 2023 Dec 20.

Article en En | MEDLINE | ID: mdl-38051230

RESUMEN

Construction of the sterically demanding Csp2(oS)-Csp3(T) bond was achieved by carrying out the Pd-catalyzed carboxylate-directed Mizoroki-Heck reaction under extra-ligand-free aqueous conditions. The cooperative role of the presence of water with the absence of phosphine ligand was proposed to accelerate the migratory insertion process considerably, delivering a broad substrate scope.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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