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A Proof-of-Concept Study on the Theranostic Potential of 177 Lu-labeled Biocompatible Covalent Polymer Nanoparticles for Cancer Targeted Radionuclide Therapy.
Chen, Xijian; Tan, Fuyuan; Liang, Ranxi; Liao, Jiali; Yang, Jijun; Lan, Tu; Yang, Yuanyou; Liu, Ning; Li, Feize.
Afiliación
  • Chen X; Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, No. 29, Wang Jiang Road, Sichuan Province, Chengdu, 610064, P. R. China.
  • Tan F; Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, No. 29, Wang Jiang Road, Sichuan Province, Chengdu, 610064, P. R. China.
  • Liang R; Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, No. 29, Wang Jiang Road, Sichuan Province, Chengdu, 610064, P. R. China.
  • Liao J; Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, No. 29, Wang Jiang Road, Sichuan Province, Chengdu, 610064, P. R. China.
  • Yang J; Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, No. 29, Wang Jiang Road, Sichuan Province, Chengdu, 610064, P. R. China.
  • Lan T; Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, No. 29, Wang Jiang Road, Sichuan Province, Chengdu, 610064, P. R. China.
  • Yang Y; Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, No. 29, Wang Jiang Road, Sichuan Province, Chengdu, 610064, P. R. China.
  • Liu N; Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, No. 29, Wang Jiang Road, Sichuan Province, Chengdu, 610064, P. R. China.
  • Li F; Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, No. 29, Wang Jiang Road, Sichuan Province, Chengdu, 610064, P. R. China.
Chemistry ; 30(9): e202303298, 2024 Feb 12.
Article en En | MEDLINE | ID: mdl-38050716
Theranostic nanomedicine combined bioimaging and therapy probably rises more helpful and interesting opportunities for personalized medicine. In this work, 177 Lu radiolabeling and surface PEGylation of biocompatible covalent polymer nanoparticles (CPNs) have generated a new theranostic nanoformulation (177 Lu-DOTA-PEG-CPNs) for targeted diagnosis and treatment of breast cancer. The in vitro anticancer investigations demonstrate that 177 Lu-DOTA-PEG-CPNs possess excellent bonding capacity with breast cancer cells (4T1), inhibiting the cell viability, leading to cell apoptosis, arresting the cell cycle, and upregulating the reactive oxygen species (ROS), which can be attributed to the good targeting ability of the nanocarrier and the strong relative biological effect of the radionuclide labelled compound. Single photon emission computed tomography/ computed tomography (SPECT/CT) imaging and in vivo biodistribution based on 177 Lu-DOTA-PEG-CPNs reveal that notable radioactivity accumulation at tumor site in murine 4T1 models with both intravenous and intratumoral administration of the prepared radiotracer. Significant tumor inhibition has been observed in mice treated with 177 Lu-DOTA-PEG-CPNs, of which the median survival was highly extended. More strikingly, 50 % of mice intratumorally injected with 177 Lu-DOTA-PEG-CPNs was cured and showed no tumor recurrence within 90 days. The outcome of this work can provide new hints for traditional nanomedicines and promote clinical translation of 177 Lu radiolabeled compounds efficiently.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Neoplasias Límite: Animals Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Neoplasias Límite: Animals Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Alemania