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Development and validation of a blood routine-based extent and severity clinical decision support tool for ulcerative colitis.
Chen, Hongliang; Lin, Xindi; Pan, Xinyue; Xu, Hongyu; Zhang, Xuemei; Liang, Guoying; Qiu, Jiawei; Zhang, Xueyan; Gao, Yang; Tan, Xin; Li, Ning; Cai, Huimin; Cang, Xueyu; Qi, Jihan; Li, Wei; Li, Shuang; Zheng, Yutong; Zhao, Lei; Jin, Shizhu.
Afiliación
  • Chen H; Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang, China.
  • Lin X; Department of Statistics, University of Wisconsin, Madison, WI, USA.
  • Pan X; School of Economics and Finance, Xi'an Jiaotong University, Xi'an, China.
  • Xu H; Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Zhang X; Department of Gastroenterology, The First Affiliated Hospital of Jiamusi University, Jiamusi, China.
  • Liang G; Department of Liver, Spleen and Stomach Diseases, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
  • Qiu J; Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang, China.
  • Zhang X; Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang, China.
  • Gao Y; Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang, China.
  • Tan X; Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Li N; Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang, China.
  • Cai H; Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang, China.
  • Cang X; Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang, China.
  • Qi J; Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang, China.
  • Li W; Department of Gastroenterology, The First Affiliated Hospital of Jiamusi University, Jiamusi, China.
  • Li S; Department of Gastroenterology, The First Affiliated Hospital of Jiamusi University, Jiamusi, China.
  • Zheng Y; Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang, China.
  • Zhao L; Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang, China.
  • Jin S; Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang, China. drshizhujin@hrbmu.edu.cn.
Sci Rep ; 13(1): 21368, 2023 12 04.
Article en En | MEDLINE | ID: mdl-38049548
Monitoring extent and severity is vital in the ulcerative colitis (UC) follow-up, however, current assessment is complex and low cost-effectiveness. We aimed to develop a routine blood-based clinical decision support tool, Jin's model, to investigate the extent and severity of UC. The multicentre retrospective cohort study recruited 975 adult UC inpatients and sub-grouped into training, internal validation and external validation set. Model was developed by logistics regression for the extent via Montreal classification and for the severity via Mayo score, Truelove and Witts score (TWS), Mayo endoscopic score (MES) and Degree of Ulcerative colitis Burden of Luminal Inflammation (DUBLIN) score. In Montreal classification, left-sided and extensive versus proctitis model achieved area under the receiver operating characteristic curve (AUROC) of 0.78 and 0.81 retrospectively. For severity, Mayo score model, TWS model, MES model and DUBLIN score model achieved an AUROC of 0.81, 0.70, 0.74 and 0.70 retrospectively. The models also were evaluated with satisfactory calibration and clinical unity. Jin's model was free with open access at http://jinmodel.com:3000/ . Jin's model is a noninvasive, convenient, and efficient approach to assess the extent and severity of UC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Sistemas de Apoyo a Decisiones Clínicas Límite: Adult / Humans Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Sistemas de Apoyo a Decisiones Clínicas Límite: Adult / Humans Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido