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Dietary fish oil enriched in very-long-chain polyunsaturated fatty acid reduces cardiometabolic risk factors and improves retinal function.
Yang, Zhi-Hong; Gorusupudi, Aruna; Lydic, Todd A; Mondal, Anupam K; Sato, Seizo; Yamazaki, Isao; Yamaguchi, Hideaki; Tang, Jingrong; Rojulpote, Krishna Vamsi; Lin, Anna B; Decot, Hannah; Koch, Hannah; Brock, Daniel C; Arunkumar, Ranganathan; Shi, Zhen-Dan; Yu, Zu-Xi; Pryor, Milton; Kun, Julia F; Swenson, Rolf E; Swaroop, Anand; Bernstein, Paul S; Remaley, Alan T.
Afiliación
  • Yang ZH; Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  • Gorusupudi A; Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, Salt Lake City, UT 84132, USA.
  • Lydic TA; Department of Physiology, Collaborative Mass Spectrometry Core, Michigan State University, East Lansing, MI 48824, USA.
  • Mondal AK; Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, NIH, Bethesda, MD 20892, USA.
  • Sato S; Central Research Laboratory, Nissui Corporation, 1-32-3 Nanakuni, Hachioji, Tokyo 192-0991, Japan.
  • Yamazaki I; Central Research Laboratory, Nissui Corporation, 1-32-3 Nanakuni, Hachioji, Tokyo 192-0991, Japan.
  • Yamaguchi H; Central Research Laboratory, Nissui Corporation, 1-32-3 Nanakuni, Hachioji, Tokyo 192-0991, Japan.
  • Tang J; Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  • Rojulpote KV; Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  • Lin AB; Department of Physiology, Collaborative Mass Spectrometry Core, Michigan State University, East Lansing, MI 48824, USA.
  • Decot H; Department of Physiology, Collaborative Mass Spectrometry Core, Michigan State University, East Lansing, MI 48824, USA.
  • Koch H; Department of Physiology, Collaborative Mass Spectrometry Core, Michigan State University, East Lansing, MI 48824, USA.
  • Brock DC; Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, NIH, Bethesda, MD 20892, USA.
  • Arunkumar R; Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, Salt Lake City, UT 84132, USA.
  • Shi ZD; Chemistry and Synthesis Center, NHLBI, NIH, Bethesda, MD 20892, USA.
  • Yu ZX; Pathology Core, NHLBI, NIH, Bethesda, MD 20892, USA.
  • Pryor M; Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  • Kun JF; Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  • Swenson RE; Chemistry and Synthesis Center, NHLBI, NIH, Bethesda, MD 20892, USA.
  • Swaroop A; Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, NIH, Bethesda, MD 20892, USA.
  • Bernstein PS; Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, Salt Lake City, UT 84132, USA.
  • Remaley AT; Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
iScience ; 26(12): 108411, 2023 Dec 15.
Article en En | MEDLINE | ID: mdl-38047069
Very-long-chain polyunsaturated fatty acids (VLCPUFAs; C24-38) constitute a unique class of PUFA that have important biological roles, but the lack of a suitable dietary source has limited research in this field. We produced an n-3 C24-28-rich VLCPUFA-oil concentrated from fish oil to study its bioavailability and physiological functions in C57BL/6J mice. The serum and retinal C24:5 levels increased significantly compared to control after a single-dose gavage, and VLCPUFAs were incorporated into the liver, brain, and eyes after 8-week supplementation. Dietary VLCPUFAs resulted in favorable cardiometabolic changes, and improved electroretinography responses and visual performance. VLCPUFA supplementation changed the expression of genes involved in PPAR signaling pathways. Further in vitro studies demonstrated that the VLCPUFA-oil and chemically synthesized C24:5 are potent agonists for PPARs. The multiple potential beneficial effects of fish oil-derived VLCPUFAs on cardiometabolic risk and eye health in mice support future efforts to develop VLCPUFA-oil into a supplemental therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos