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Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy.
Cao, Jiangjun; Zhang, Zhe; Zhou, Li; Luo, Maochao; Li, Lei; Li, Bowen; Nice, Edouard C; He, Weifeng; Zheng, Shaojiang; Huang, Canhua.
Afiliación
  • Cao J; West China School of Basic Medical Sciences and Forensic Medicine, and Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China.
  • Zhang Z; Zhejiang Provincial Key Laboratory of Pancreatic Disease the First Affiliated Hospital School of Medicine Zhejiang University Zhejiang China.
  • Zhou L; Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Department of Infectious Diseases the Second Affiliated Hospital Institute for Viral Hepatitis, Chongqing Medical University Chongqing China.
  • Luo M; West China School of Basic Medical Sciences and Forensic Medicine, and Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China.
  • Li L; Department of anorectal surgery Hospital of Chengdu University of Traditional Chinese Medicine and Chengdu University of Traditional Chinese Medicine Chengdu China.
  • Li B; West China School of Basic Medical Sciences and Forensic Medicine, and Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China.
  • Nice EC; Department of Biochemistry and Molecular Biology Monash University Clayton VIC Australia.
  • He W; State Key Laboratory of Trauma Burn and Combined Injury Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing China.
  • Zheng S; Hainan Cancer Medical Center of The First Affiliated Hospital, the Hainan Branch of National Clinical Research Center for Cancer, Hainan Engineering Research Center for Biological Sample Resources of Major Diseases Hainan Medical University Haikou China.
  • Huang C; Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province, Hainan Women and Children's Medical Center, Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical University Haikou China.
MedComm (2020) ; 4(6): e427, 2023 Dec.
Article en En | MEDLINE | ID: mdl-38045829
Emerging evidence indicates that cancer cells can mimic characteristics of embryonic development, promoting their development and progression. Cancer cells share features with embryonic development, characterized by robust proliferation and differentiation regulated by signaling pathways such as Wnt, Notch, hedgehog, and Hippo signaling. In certain phase, these cells also mimic embryonic diapause and fertilized egg implantation to evade treatments or immune elimination and promote metastasis. Additionally, the upregulation of ATP-binding cassette (ABC) transporters, including multidrug resistance protein 1 (MDR1), multidrug resistance-associated protein 1 (MRP1), and breast cancer-resistant protein (BCRP), in drug-resistant cancer cells, analogous to their role in placental development, may facilitate chemotherapy efflux, further resulting in treatment resistance. In this review, we concentrate on the underlying mechanisms that contribute to tumor development and progression from the perspective of embryonic development, encompassing the dysregulation of developmental signaling pathways, the emergence of dormant cancer cells, immune microenvironment remodeling, and the hyperactivation of ABC transporters. Furthermore, we synthesize and emphasize the connections between cancer hallmarks and embryonic development, offering novel insights for the development of innovative cancer treatment strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: MedComm (2020) Año: 2023 Tipo del documento: Article Pais de publicación: China
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: MedComm (2020) Año: 2023 Tipo del documento: Article Pais de publicación: China