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Inflammatory Conditions During Pregnancy and Risk of Autism and Other Neurodevelopmental Disorders.
Croen, Lisa A; Ames, Jennifer L; Qian, Yinge; Alexeeff, Stacey; Ashwood, Paul; Gunderson, Erica P; Wu, Yvonne W; Boghossian, Andrew S; Yolken, Robert; Van de Water, Judy; Weiss, Lauren A.
Afiliación
  • Croen LA; Division of Research, Kaiser Permanente Northern California, Oakland, California.
  • Ames JL; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California.
  • Qian Y; Division of Research, Kaiser Permanente Northern California, Oakland, California.
  • Alexeeff S; Division of Research, Kaiser Permanente Northern California, Oakland, California.
  • Ashwood P; Division of Research, Kaiser Permanente Northern California, Oakland, California.
  • Gunderson EP; Department of Medical Microbiology and Immunology and the MIND Institute, University of California, Davis, Davis, California.
  • Wu YW; Division of Research, Kaiser Permanente Northern California, Oakland, California.
  • Boghossian AS; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California.
  • Yolken R; Departments of Neurology and Pediatrics, University of California San Francisco, San Francisco, California.
  • Van de Water J; Institute for Human Genetics, Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California.
  • Weiss LA; Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
Biol Psychiatry Glob Open Sci ; 4(1): 39-50, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38045769
ABSTRACT

Background:

Maternal inflammation can result from immune dysregulation and metabolic perturbations during pregnancy. Whether conditions associated with inflammation during pregnancy increase the likelihood of autism spectrum disorder (ASD) or other neurodevelopmental disorders (DDs) is not well understood.

Methods:

We conducted a case-control study among children born in California from 2011 to 2016 to investigate maternal immune-mediated and cardiometabolic conditions during pregnancy and risk of ASD (n = 311) and DDs (n = 1291) compared with children from the general population (n = 967). Data on maternal conditions and covariates were retrieved from electronic health records. Maternal genetic data were used to assess a causal relationship.

Results:

Using multivariable logistic regression, we found that mothers with asthma were more likely to deliver infants later diagnosed with ASD (odds ratio [OR] = 1.62, 95% CI 1.15-2.29) or DDs (OR = 1.30, 95% CI 1.02-1.64). Maternal obesity was also associated with child ASD (OR = 1.51, 95% CI 1.07-2.13). Mothers with both asthma and extreme obesity had the greatest odds of delivering an infant later diagnosed with ASD (OR = 16.9, 95% CI 5.13-55.71). These increased ASD odds were observed among female children only. Polygenic risk scores for obesity, asthma, and their combination showed no association with ASD risk. Mendelian randomization did not support a causal relationship between maternal conditions and ASD.

Conclusions:

Inflammatory conditions during pregnancy are associated with risk for neurodevelopmental disorders in children. These risks do not seem to be due to shared genetic risk; rather, inflammatory conditions may share nongenetic risk factors with neurodevelopmental disorders. Children whose mothers have both asthma and obesity during pregnancy may benefit from earlier screening and intervention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biol Psychiatry Glob Open Sci Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biol Psychiatry Glob Open Sci Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos