Altering relative metal-binding affinities in multifunctional Metallochaperones for mutant p53 reactivation.

Kwan, Kalvin; Castro-Sandoval, Omar; Ma, Benjamin; Martelino, Diego; Saffari, Ashkan; Liu, Xi Lan; Orvain, Christophe; Mellitzer, Georg; Gaiddon, Christian; Storr, Tim

Kwan, Kalvin; Castro-Sandoval, Omar; Ma, Benjamin; Martelino, Diego; Saffari, Ashkan; Liu, Xi Lan; Orvain, Christophe; Mellitzer, Georg; Gaiddon, Christian; Storr, Tim.

Afiliación

Kwan K; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Castro-Sandoval O; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Ma B; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Martelino D; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Saffari A; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Liu XL; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Orvain C; Inserm UMR_S 1113, Université de Strasbourg, Molecular Mechanisms of Stress Response and Pathologies, Strasbourg, France.
Mellitzer G; Inserm UMR_S 1113, Université de Strasbourg, Molecular Mechanisms of Stress Response and Pathologies, Strasbourg, France.
Gaiddon C; Inserm UMR_S 1113, Université de Strasbourg, Molecular Mechanisms of Stress Response and Pathologies, Strasbourg, France. Electronic address: gaiddon@unistra.fr.
Storr T; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada. Electronic address: tim_storr@sfu.ca.

J Inorg Biochem ; 251: 112433, 2024 02.

Article en En | MEDLINE | ID: mdl-38043136

Asunto(s)

Metalochaperonas; Proteína p53 Supresora de Tumor; Zinc; Humanos; Línea Celular Tumoral; Quelantes; Metalochaperonas/química; Especies Reactivas de Oxígeno/metabolismo; Proteína p53 Supresora de Tumor/genética; Proteína p53 Supresora de Tumor/metabolismo; Zinc/metabolismo; Unión Proteica

Palabras clave

Cytotoxicity; Ligand design; Metallochaperones; ROS; p53 protein

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zinc / Proteína p53 Supresora de Tumor / Metalochaperonas Límite: Humans Idioma: En Revista: J Inorg Biochem Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

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