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Analysis of in-patient evolution of Escherichia coli reveals potential links to relapse of bone and joint infections.
Thiriet-Rupert, Stanislas; Josse, Jérôme; Perez-Pascual, David; Tasse, Jason; Andre, Camille; Abad, Lélia; Lebeaux, David; Ghigo, Jean-Marc; Laurent, Frédéric; Beloin, Christophe.
Afiliación
  • Thiriet-Rupert S; Institut Pasteur, Université de Paris-Cité, Genetics of Biofilms Laboratory F- 75015 Paris, France.
  • Josse J; CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, 69007, France.
  • Perez-Pascual D; Institut Pasteur, Université de Paris-Cité, Genetics of Biofilms Laboratory F- 75015 Paris, France.
  • Tasse J; CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, 69007, France.
  • Andre C; CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, 69007, France.
  • Abad L; CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, 69007, France.
  • Lebeaux D; Institut Pasteur, Université de Paris-Cité, Genetics of Biofilms Laboratory F- 75015 Paris, France.
  • Ghigo JM; Département de Maladies Infectieuses et Tropicales, AP-HP, Hôpital Saint-Louis, Lariboisière, F-75010 Paris, France.
  • Laurent F; FHU PROTHEE.
  • Beloin C; Institut Pasteur, Université de Paris-Cité, Genetics of Biofilms Laboratory F- 75015 Paris, France.
J Infect Dis ; 2023 Dec 02.
Article en En | MEDLINE | ID: mdl-38041851
Bone and joint infections (BJIs) are difficult to treat and affect a growing number of patients, in which relapses are observed in 10-20% of the case. These relapses, which call for prolonged antibiotic treatment and increase resistance emergence risk, may originate from ill understood adaptation of the pathogen to the host. Here, we investigated three pairs of Escherichia coli strains from BJI cases and their relapses to unravel in-patient adaptation. Whole genome comparison presented evidence for positive selection and phenotypic characterization showed that biofilm formation remained unchanged, contrary to what is usually described in such cases. Although virulence was not modified, we identified the loss of two virulence factors contributing to immune system evasion in one of the studied strains. Other strategies, including global growth optimization and colicin production, likely allowed the strains to outcompete competitors. This work highlights the variety of strategies allowing in-patient adaptation in BJIs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Infect Dis Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Infect Dis Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos