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Neural patterns differentiate traumatic from sad autobiographical memories in PTSD.
Perl, Ofer; Duek, Or; Kulkarni, Kaustubh R; Gordon, Charles; Krystal, John H; Levy, Ifat; Harpaz-Rotem, Ilan; Schiller, Daniela.
Afiliación
  • Perl O; Center for Computational Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Duek O; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Kulkarni KR; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Gordon C; Department of Epidemiology, Biostatistics and Community Health Sciences, School of Public Health, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
  • Krystal JH; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
  • Levy I; The National Center for PTSD, VA CT Healthcare System, West Haven, CT, USA.
  • Harpaz-Rotem I; Center for Computational Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Schiller D; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nat Neurosci ; 26(12): 2226-2236, 2023 Dec.
Article en En | MEDLINE | ID: mdl-38036701
For people with post-traumatic stress disorder (PTSD), recall of traumatic memories often displays as intrusions that differ profoundly from processing of 'regular' negative memories. These mnemonic features fueled theories speculating a unique cognitive state linked with traumatic memories. Yet, to date, little empirical evidence supports this view. Here we examined neural activity of patients with PTSD who were listening to narratives depicting their own memories. An intersubject representational similarity analysis of cross-subject semantic content and neural patterns revealed a differentiation in hippocampal representation by narrative type: semantically similar, sad autobiographical memories elicited similar neural representations across participants. By contrast, within the same individuals, semantically similar trauma memories were not represented similarly. Furthermore, we were able to decode memory type from hippocampal multivoxel patterns. Finally, individual symptom severity modulated semantic representation of the traumatic narratives in the posterior cingulate cortex. Taken together, these findings suggest that traumatic memories are an alternative cognitive entity that deviates from memory per se.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Memoria Episódica Límite: Humans Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Memoria Episódica Límite: Humans Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos