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Delayed Collagen Production without Myofibroblast Formation Contributes to Reduced Scarring in Adult Skin Microwounds.
Kuan, Chen-Hsiang; Tai, Kang-Yu; Lu, Shao-Chi; Wu, Yueh-Feng; Wu, Pei-Shan; Kwang, Nellie; Wang, Wei-Hung; Mai-Yi Fan, Sabrina; Wang, Shiou-Han; Chien, Hsiung-Fei; Lai, Hong-Shiee; Lin, Miao-Hsia; Plikus, Maksim V; Lin, Sung-Jan.
Afiliación
  • Kuan CH; Graduate Institute of Clinical Research, College of Medicine, National Taiwan University, Taipei, Taiwan; Division of Plastic Surgery, Department of Surgery, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan; Research Center for Developmental Biology and Regenerative Medicine,
  • Tai KY; Genome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei, Taiwan.
  • Lu SC; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
  • Wu YF; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
  • Wu PS; Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
  • Kwang N; Department of Developmental and Cell Biology, School of Biological Sciences, University of California, Irvine, Irvine, California, USA.
  • Wang WH; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
  • Mai-Yi Fan S; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.
  • Wang SH; Department of Dermatology, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan.
  • Chien HF; Division of Plastic Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan; TMU Center for Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, Taiwan.
  • Lai HS; Department of Surgery, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan; Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  • Lin MH; Graduate Institute and Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
  • Plikus MV; Department of Developmental and Cell Biology, School of Biological Sciences, University of California, Irvine, Irvine, California, USA; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, California, USA; Sue and Bill Gross Stem Cell Research Center, Univer
  • Lin SJ; Graduate Institute of Clinical Research, College of Medicine, National Taiwan University, Taipei, Taiwan; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan; Department of Biomedical Engineering, College of Medicine and College of Engineer
J Invest Dermatol ; 2023 Nov 29.
Article en En | MEDLINE | ID: mdl-38036291
In adult mammals, wound healing predominantly follows a fibrotic pathway, culminating in scar formation. However, cutaneous microwounds generated through fractional photothermolysis, a modality that produces a constellation of microthermal zones, exhibit a markedly different healing trajectory. Our study delineates the cellular attributes of these microthermal zones, underscoring a temporally limited, subclinical inflammatory milieu concomitant with rapid re-epithelialization within 24 hours. This wound closure is facilitated by the activation of genes associated with keratinocyte migration and differentiation. In contrast to macrothermal wounds, which predominantly heal through a robust myofibroblast-mediated collagen deposition, microthermal zones are characterized by absence of wound contraction and feature delayed collagen remodeling, initiating 5-6 weeks after injury. This distinct wound healing is characterized by a rapid re-epithelialization process and a muted inflammatory response, which collectively serve to mitigate excessive myofibroblast activation. Furthermore, we identify an initial reparative phase characterized by a heterogeneous extracellular matrix protein composition, which precedes the delayed collagen remodeling. These findings extend our understanding of cutaneous wound healing and may have significant implications for the optimization of therapeutic strategies aimed at mitigating scar formation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Invest Dermatol Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Invest Dermatol Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos