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SPME as a green sample-preparation technique for the monitoring of phytocannabinoids and endocannabinoids in complex matrices.
Wozniczka, Katarzyna; Konieczynski, Pawel; Plenis, Alina; Baczek, Tomasz; Roszkowska, Anna.
Afiliación
  • Wozniczka K; Department of Pharmaceutical Chemistry, Medical University of Gdansk, Gdansk, Poland.
  • Konieczynski P; Department of Analytical Chemistry, Medical University of Gdansk, Gdansk, Poland.
  • Plenis A; Department of Analytical Chemistry, Medical University of Gdansk, Gdansk, Poland.
  • Baczek T; Department of Pharmaceutical Chemistry, Medical University of Gdansk, Gdansk, Poland.
  • Roszkowska A; Department of Pharmaceutical Chemistry, Medical University of Gdansk, Gdansk, Poland.
J Pharm Anal ; 13(10): 1117-1134, 2023 Oct.
Article en En | MEDLINE | ID: mdl-38024858
The endocannabinoid system (ECS), particularly its signaling pathways and ligands, has garnered considerable interest in recent years. Along with clinical work investigating the ECS' functions, including its role in the development of neurological and inflammatory conditions, much research has focused on developing analytical protocols enabling the precise monitoring of the levels and metabolism of the most potent ECS ligands: exogenous phytocannabinoids (PCs) and endogenous cannabinoids (endocannabinoids, ECs). Solid-phase microextraction (SPME) is an advanced, non-exhaustive sample-preparation technique that facilitates the precise and efficient isolation of trace amounts of analytes, thus making it appealing for the analysis of PCs and ECs in complex matrices of plant and animal/human origin. In this paper, we review recent forensic medicine and toxicological studies wherein SPME has been applied to monitor levels of PCs and ECs in complex matrices, determine their effects on organism physiology, and assess their role in the development of several diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Pharm Anal Año: 2023 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Pharm Anal Año: 2023 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: China