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The efficacy of Allium ampeloprasum L. in reducing neutrophil recovery time in childhood cancer with febrile neutropenia: a randomized, double-blind, placebo-controlled trial.
Bordbar, Mohammadreza; Vahidifar, Mehdi; Zarshenas, Mohammad Mehdi; Haghpanah, Sezaneh; Zareifar, Soheila; Shahriari, Mahdi; Zekavat, Omid Reza; Karimi, Mehran; Fathpour, Gholamreza; Zargaran, Arman; Shakibazad, Nader.
Afiliación
  • Bordbar M; Hematology Research Center, Shiraz University of Medical Sciences Shiraz, Iran.
  • Vahidifar M; Department of Pediatrics, Division of Pediatric Hematology and Oncology, Shiraz University of Medical Sciences Shiraz, Iran.
  • Zarshenas MM; Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences Shiraz, Iran.
  • Haghpanah S; Hematology Research Center, Shiraz University of Medical Sciences Shiraz, Iran.
  • Zareifar S; Hematology Research Center, Shiraz University of Medical Sciences Shiraz, Iran.
  • Shahriari M; Department of Pediatrics, Division of Pediatric Hematology and Oncology, Shiraz University of Medical Sciences Shiraz, Iran.
  • Zekavat OR; Hematology Research Center, Shiraz University of Medical Sciences Shiraz, Iran.
  • Karimi M; Hematology Research Center, Shiraz University of Medical Sciences Shiraz, Iran.
  • Fathpour G; Department of Pediatrics, Division of Pediatric Hematology and Oncology, Shiraz University of Medical Sciences Shiraz, Iran.
  • Zargaran A; Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Tehran University of Medical Sciences Tehran, Iran.
  • Shakibazad N; Hematology Research Center, Shiraz University of Medical Sciences Shiraz, Iran.
Am J Blood Res ; 13(5): 143-151, 2023.
Article en En | MEDLINE | ID: mdl-38023416
INTRODUCTION: Febrile neutropenia is a serious complication of cancer chemotherapy that can result in delays in treatment. This study evaluates the efficacy of A. ampeloprasum L. at neutrophil recovery time in children with chemotherapy-associated febrile neutropenia. METHODS: This single-center, parallel-group, double-blind, randomized clinical trial was conducted at an oncology hospital. Patients selected among childhood cancers with febrile neutropenia. Overall, 97 febrile neutropenic children were enrolled. The intervention group (n=49) was given A. ampeloprasum L. in capsules (500 mg twice daily) for seven days plus supportive care. The control group (n=48) was treated similarly with supportive care and placebo capsules. Total white blood cell (WBC) and absolute neutrophil counts (ANC) were checked daily and neutrophil recovery time in both groups was compared. RESULTS: Patients in the intervention group experienced shorter neutrophil recovery compared to the control group (4.02 ± 2.32 days vs. 6.38 ± 2.80 days, respectively, P less than 0.001). The intervention group was discharged from the hospital earlier than the control group with a mean of two days, but it did not reach statistical significance (P=0.133). Mean WBC and ANC were not significantly different in the two groups. Herbal medicine was well tolerated, and no adverse effect was reported. CONCLUSIONS: A fresh, lyophilized extract from deciduous leaves of A. ampeloprasum L. can effectively shorten the ANC recovery time leading to an earlier release from the hospital. The trial was registered in the Iranian Registry of Clinical Trials with registration No. IRCT2015051615666N2 (http://www.irct.ir/).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Blood Res Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Blood Res Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos