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Regional neuroinflammation induced by peripheral infection contributes to fatigue-like symptoms: a [18F]DPA-714 positron emission tomography study in rats.
Li, Danxi; Hu, Di; Ochi, Yuta; Arakaki, Wakiko; Mawatari, Aya; Shigeta, Mika; Wu, Yuping; Hayashinaka, Emi; Neyama, Hiroyuki; Tahara, Tsuyoshi; Wada, Yasuhiro; Li, Feng; Doi, Hisashi; Watanabe, Yasuyoshi; Cui, Yilong.
Afiliación
  • Li D; Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
  • Hu D; Department of Chinese Medicine Diagnostics, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
  • Ochi Y; Institute for Brain Disorders, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
  • Arakaki W; Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
  • Mawatari A; Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
  • Shigeta M; Laboratory for Labeling Chemistry, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
  • Wu Y; Laboratory for Labeling Chemistry, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
  • Hayashinaka E; Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
  • Neyama H; Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
  • Tahara T; Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
  • Wada Y; Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
  • Li F; Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
  • Doi H; Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
  • Watanabe Y; Department of Chinese Medicine Diagnostics, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
  • Cui Y; Laboratory for Labeling Chemistry, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Front Immunol ; 14: 1261256, 2023.
Article en En | MEDLINE | ID: mdl-38022622
Introduction: A series of symptoms, including fever, widespread pain, fatigue, and even ageusia, have frequently been reported in the context of various infections, such as COVID-19. Although the pathogenic mechanisms underlying an infection causing fever and pain have been well established, the mechanisms of fatigue induced by infection in specific brain regions remain unclear. Methods: To elucidate whether and how the peripheral infection cause fatigue via regional neuroinflammation, we performed a brain-wide investigation of neuroinflammation in a peripheral pseudoinfection rat model using [18F]DPA-714 positron emission tomography (PET) imaging analysis, in which the polyriboinosinic: polyribocytidylic acid (poly I:C) was intraperitoneally injected. Results: Transient fever lasting for several hours and subsequent suppression of spontaneous activity lasting a few days were induced by poly I:C treatment. Significant increase in plasma interleukin (IL)-1ß, IL-6 and tumour necrosis factor (TNF)-α were observed at 2 and 4 h following poly I:C treatment. PET imaging analysis revealed that the brain uptake of [18F]DPA-714 was significantly increased in several brain regions one day after poly I:C treatment, such as the dorsal raphe (DR), parvicellular part of red nucleus (RPC), A5 and A7 noradrenergic nucleus, compared with the control group. The accumulation of [18F]DPA-714 in the DR, RPC and A5 was positively correlated with subsequent fatigue-like behavior, and that in the A7 tended to positively correlate with fever. Discussion: These findings suggest that peripheral infection may trigger regional neuroinflammation, which may cause specific symptoms such as fatigue. A similar mechanism might be involved in COVID-19.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Enfermedades Neuroinflamatorias Límite: Animals Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Enfermedades Neuroinflamatorias Límite: Animals Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza