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Single-Center Outcomes of WATCHMAN™ Implantation with Comparison to Oral Anticoagulant and Dual Antiplatelet Therapy.
Demiraj, Francis; Benrubi, Michael S; Babici, Denis; Muharremi, Eti; Pachon, Ronald; Osman, Ahmed.
Afiliación
  • Demiraj F; Department of Neurology, Florida Atlantic University Charles E. Schmidt College of Medicine, Marcus Neuroscience Institute, Boca Raton, USA.
  • Benrubi MS; Department of Neurology, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Boca Raton, USA.
  • Babici D; Department of Neurology, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
  • Muharremi E; Department of Neurology, Columbia University Irving Medical Center, New York, USA.
  • Pachon R; Department of Cardiology, University of Miami, Miami, USA.
  • Osman A; Department of Cardiology, Broward General Medical Center, Fort Lauderdale, USA.
Cureus ; 15(10): e47444, 2023 Oct.
Article en En | MEDLINE | ID: mdl-38021921
Background The WATCHMAN™ device is a Food and Drug Administration (FDA)-approved device that reduces the risk of stroke from atrial fibrillation (AF) in those who have a contraindication to taking oral anticoagulation. A key aspect of this device implantation is the choice of medical therapy in the months after device implantation with Vitamin K antagonist oral anticoagulants (OAC) being the mainstay of therapy but dual antiplatelet therapy (DAPT) poses as a potential alternative to patients who have a contraindication to OAC use. Methods Our single-center study retroactively followed 150 patients post-WATCHMAN™ implantation and evaluated outcomes at 12 months post-implantation in two cohorts, those treated with OAC or DAPT. Our results were obtained via chart review of a single-center electronic medical records system. Results In our study, 67.33% of study patients were males and 49.33% were on OAC compared to 36.00% that were on DAPT. Ten patients were not able to undergo device implantation. With this analysis, we found similarly low rates of complications such as stroke and device-associated thrombosis (DAT) in both groups. Our DAPT cohort did have a higher number of gastrointestinal (GI) bleeding but this was not significant in our analysis. Discussion Our study compares to larger trials that show similar outcomes between OAC and DAPT post-implantation of the WATCHMAN™ device. The increased number of GI bleeding in our DAPT cohort could be the result of the underlying advanced age and comorbidity of that patient cohort. Conclusion Our results suggest that DAPT is a safe alternative to OAC for patients undergoing WATCHMAN™ implantation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos