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Establishment of cell culture model and humanized mouse model of chronic hepatitis B virus infection.
Tian, Renyun; Yang, Di; Xu, Biaoming; Deng, Rilin; Xue, Binbin; Wang, Luoling; Li, Huiyi; Liu, Qian; Wang, Xiaohong; Tang, Songqing; Wan, Mengyu; Pei, Hua; Zhu, Haizhen.
Afiliación
  • Tian R; Institute of Pathogen Biology and Immunology, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, China.
  • Yang D; Institute of Pathogen Biology and Immunology, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, China.
  • Xu B; Institute of Pathogen Biology and Immunology, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, China.
  • Deng R; Institute of Pathogen Biology and Immunology, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, China.
  • Xue B; Institute of Pathogen Biology and Immunology, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, China.
  • Wang L; Institute of Pathogen Biology and Immunology, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, China.
  • Li H; Institute of Pathogen Biology and Immunology, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, China.
  • Liu Q; Institute of Pathogen Biology and Immunology, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, China.
  • Wang X; Institute of Pathogen Biology and Immunology, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, China.
  • Tang S; Institute of Pathogen Biology and Immunology, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, China.
  • Wan M; Institute of Pathogen Biology and Immunology, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, China.
  • Pei H; Department of Pathogen Biology and Immunology, Department of Clinical Laboratory of the Second Affiliated Hospital, Key Laboratory of Tropical Translational Medicine of Ministry of Education,Institute of Pathogen Biology and Immunology,School of Basic Medicine and Life Science, The University of Hon
  • Zhu H; Institute of Pathogen Biology and Immunology, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha, China.
Microbiol Spectr ; 12(1): e0274523, 2024 Jan 11.
Article en En | MEDLINE | ID: mdl-38018998
IMPORTANCE: Approximately 257 million people worldwide have been infected with hepatitis B virus (HBV), and HBV infection can cause chronic hepatitis, cirrhosis, and even liver cancer. The lack of suitable and effective infection models has greatly limited research in HBV-related fields for a long time, and it is still not possible to discover a method to completely and effectively remove the HBV genome. We have constructed a hepatocellular carcinoma cell line, HLCZ01, that can support the complete life cycle of HBV. This model can mimic the long-term stable infection of HBV in the natural state and can replace primary human hepatocytes for the development of human liver chimeric mice. This model will be a powerful tool for research in the field of HBV.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hepatitis B Crónica / Hepatitis B Límite: Animals / Humans Idioma: En Revista: Microbiol Spectr Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hepatitis B Crónica / Hepatitis B Límite: Animals / Humans Idioma: En Revista: Microbiol Spectr Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos