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Adolescent exposure to sucrose increases cocaine-mediated behaviours in adulthood via Smad3.
Gancarz, Amy M; Parmar, Raveena; Shwani, Treefa; Cobb, Moriah M; Crawford, Michelle N; Watson, Jacob R; Evans, Lisa; Kausch, Michael A; Werner, Craig T; Dietz, David M.
Afiliación
  • Gancarz AM; Department of Psychology, California State University, Bakersfield, California, USA.
  • Parmar R; Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
  • Shwani T; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, New York, USA.
  • Cobb MM; Department of Psychology, California State University, Bakersfield, California, USA.
  • Crawford MN; Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
  • Watson JR; Department of Psychology, California State University, Bakersfield, California, USA.
  • Evans L; Department of Psychology, California State University, Bakersfield, California, USA.
  • Kausch MA; Department of Psychology, California State University, Bakersfield, California, USA.
  • Werner CT; Department of Psychology, California State University, Bakersfield, California, USA.
  • Dietz DM; Department of Psychology, California State University, Bakersfield, California, USA.
Addict Biol ; 28(12): e13346, 2023 12.
Article en En | MEDLINE | ID: mdl-38017636
Adolescence, a critical period of developmental period, is marked by neurobiological changes influenced by environmental factors. Here, we show how exposure to sucrose, which is ubiquitously available in modern diets, results in changes in behavioural response to cocaine as an adult. Rats were given daily access to either 10% sucrose or water during the adolescent period (PND28-42). Following this period, rats are left undisturbed until they reach adulthood. In adulthood, rats were tested for (i) acquisition of a low dose of cocaine, (ii) progressive ratio (PR) test, and (iii) resistance to punished cocaine taking. Sucrose exposure resulted in significant alterations in all behavioural measures. To determine the neurobiological mechanisms leading to such behavioural adaptations, we find that adolescent sucrose exposure results in an upregulation of the transcription factor Smad3 in the nucleus accumbens (NAc) when compared with water-exposed controls. Transiently blocking the active form of this transcription factor (HSV-dnSmad3) during adolescence mitigated the enhanced cocaine vulnerability-like behaviours observed in adulthood. These findings suggest that prior exposure to sucrose during adolescence can heighten the reinforcing effects of cocaine. Furthermore, they identify the TGF-beta pathway and Smad3 as playing a key role in mediating enduring and long-lasting adaptations that contribute to sucrose-induced susceptibility to cocaine. Taken together, these results have important implications for development and suggest that adolescent sucrose exposure may persistently enhance the susceptibility to substance abuse.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cocaína Límite: Animals Idioma: En Revista: Addict Biol Asunto de la revista: TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cocaína Límite: Animals Idioma: En Revista: Addict Biol Asunto de la revista: TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos