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MET-receptor targeted fluorescent imaging and spectroscopy to detect multifocal papillary thyroid cancer.
Metman, Madelon J H; Jonker, Pascal K C; Sondorp, Luc H J; van Hemel, Bettien M; Sywak, Mark S; Gill, Anthony J; Jansen, Liesbeth; van Diest, Paul J; van Ginhoven, Tessa M; Löwik, Clemens W G M; Nguyen, Anh H; Robinson, Dominic J; van Dam, Gooitzen M; Links, Thera P; Coppes, Rob P; Fehrmann, Rudolf S N; Kruijff, Schelto.
Afiliación
  • Metman MJH; Department of Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
  • Jonker PKC; Department of Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
  • Sondorp LHJ; Department of Endocrine Surgery and Surgical Oncology, Royal North Shore Hospital, St Leonards, Australia.
  • van Hemel BM; Department of Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
  • Sywak MS; Department of Biomedical Sciences of Cell & Systems - Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Gill AJ; Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Jansen L; Department of Endocrine Surgery and Surgical Oncology, Royal North Shore Hospital, St Leonards, Australia.
  • van Diest PJ; NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, Australia.
  • van Ginhoven TM; Sydney Medical School, University of Sydney, Sydney, Australia.
  • Löwik CWGM; Cancer Diagnosis and Pathology Group Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Australia.
  • Nguyen AH; Department of Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
  • Robinson DJ; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.
  • van Dam GM; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore, USA.
  • Links TP; Department of Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
  • Coppes RP; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.
  • Fehrmann RSN; Department of Pathology, Erasmus MC, Rotterdam, the Netherlands.
  • Kruijff S; Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Eur J Nucl Med Mol Imaging ; 2023 Nov 29.
Article en En | MEDLINE | ID: mdl-38017325
PURPOSE: Multifocal disease in PTC is associated with an increased recurrence rate. Multifocal disease (MD) is underdiagnosed with the current gold standard of pre-operative ultrasound staging. Here, we evaluate the use of EMI-137 targeted molecular fluorescence-guided imaging (MFGI) and spectroscopy as a tool for the intra-operative detection of uni- and multifocal papillary thyroid cancer (PTC) aiming to improve disease staging and treatment selection. METHODS: A phase-1 study (NCT03470259) with EMI-137 was conducted to evaluate the possibility of detecting PTC using MFGI and quantitative fiber-optic spectroscopy. RESULTS: Fourteen patients underwent hemi- or total thyroidectomy (TTX) after administration of 0.09 mg/kg (n = 1), 0.13 mg/kg (n = 8), or 0.18 mg/kg (n = 5) EMI-137. Both MFGI and spectroscopy could differentiate PTC from healthy thyroid tissue after administration of EMI-137, which binds selectively to MET in PTC. 0.13 mg/kg was the lowest dosage EMI-137 that allowed for differentiation between PTC and healthy thyroid tissue. The smallest PTC focus detected by MFGI was 1.4 mm. MFGI restaged 80% of patients from unifocal to multifocal PTC compared to ultrasound. CONCLUSION: EMI-137-guided MFGI and spectroscopy can be used to detect multifocal PTC. This may improve disease staging and treatment selection between hemi- and total thyroidectomy by better differentiation between unifocal and multifocal disease. TRIAL REGISTRATION: NCT03470259.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Nucl Med Mol Imaging Asunto de la revista: MEDICINA NUCLEAR Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Nucl Med Mol Imaging Asunto de la revista: MEDICINA NUCLEAR Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania