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Frailty is related to serum inflammageing markers: results from the VITAL study.
van Sleen, Yannick; Shetty, Sudarshan A; van der Heiden, Marieke; Venema, Milou C A; Gutiérrez-Melo, Nicolas; Toonen, Erik J M; van Beek, Josine; Buisman, Anne-Marie; van Baarle, Debbie; Sauce, Delphine.
Afiliación
  • van Sleen Y; University Medical Center Groningen, Groningen, The Netherlands. y.van.sleen@umcg.nl.
  • Shetty SA; University Medical Center Groningen, Groningen, The Netherlands.
  • van der Heiden M; University Medical Center Groningen, Groningen, The Netherlands.
  • Venema MCA; University Medical Center Groningen, Groningen, The Netherlands.
  • Gutiérrez-Melo N; Sorbonne Université, INSERM, Centre d'Immunologie Et Des Maladies Infectieuses, Cimi-Paris, 75013, Paris, France.
  • Toonen EJM; R&D Department, Hycult Biotechnology, Uden, the Netherlands.
  • van Beek J; Center of Infectious Diseases Control, National Institute of Public Health and the Environment, Bilthoven, Netherlands.
  • Buisman AM; Center of Infectious Diseases Control, National Institute of Public Health and the Environment, Bilthoven, Netherlands.
  • van Baarle D; University Medical Center Groningen, Groningen, The Netherlands.
  • Sauce D; Sorbonne Université, INSERM, Centre d'Immunologie Et Des Maladies Infectieuses, Cimi-Paris, 75013, Paris, France.
Immun Ageing ; 20(1): 68, 2023 Nov 27.
Article en En | MEDLINE | ID: mdl-38012652
Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adverse outcomes. To score frailty, studies have employed the questionnaires, such as the SF-36 and EQ-5D-3L, or the Frailty Index, a composite score based on deficit accumulation. Furthermore, ageing of the immune system is often accompanied by a state of low-grade inflammation (inflammageing). Here, we aimed to associate 29 circulating markers of inflammageing with frailty measures in a prospective cohort study to understand the mechanisms underlying ageing.Frailty measures and inflammageing markers were assessed in 317 participants aged 25-90. We determined four different measures of frailty: the Frailty Index based on 31 deficits, the EQ-5D-3L and two physical domains of the SF-36. Serum/plasma levels of inflammageing markers and CMV/EBV seropositivity were measured using different techniques: Quanterix, Luminex or ELISA.All four measures of frailty strongly correlated with age and BMI. Nineteen biomarkers correlated with age, some in a linear fashion (IL-6, YKL-40), some only in the oldest age brackets (CRP), and some increased at younger ages and then plateaued (CCL2, sIL-6R). After correcting for age, biomarkers, such as IL-6, CRP, IL-1RA, YKL-40 and elastase, were associated with frailty. When corrected for BMI, the number of associations reduced further.In conclusion, inflammageing markers, particularly markers reflecting innate immune activation, are related to frailty. These findings indicate that health decline and the accumulation of deficits with age is accompanied with a low-grade inflammation which can be detected by specific inflammatory markers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Immun Ageing Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Immun Ageing Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido