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Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway.
Yan, Ming-Qi; Zhu, Bing-Hong; Liu, Xiao-Hong; Yang, Yu-Meng; Duan, Xiu-Yun; Wang, Yong; Sun, Hui; Feng, Mei; Li, Tao; Liu, Xiao-Man.
Afiliación
  • Yan MQ; Department of Central Laboratory, Shandong Provincial Hospital, Shandong University, 250021, Jinan, China.
  • Zhu BH; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, 250014, Jinan, China.
  • Liu XH; Department of Infection Control, Jen Ching Memorial Hospital, 215300, Kunshan, China.
  • Yang YM; Department of Central Laboratory, Shandong Provincial Hospital, Shandong University, 250021, Jinan, China.
  • Duan XY; Department of Central Laboratory, Shandong Provincial Hospital, Shandong University, 250021, Jinan, China.
  • Wang Y; Department of Clinical Laboratory Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University; Institute of Clinical Microbiology, Shandong Academy of Clinical Medicine, 250021, Jinan, China.
  • Sun H; Department of Clinical Laboratory Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University; Institute of Clinical Microbiology, Shandong Academy of Clinical Medicine, 250021, Jinan, China.
  • Feng M; Department of Central Laboratory, Shandong Provincial Hospital, Shandong University, 250021, Jinan, China.
  • Li T; Department of Central Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, Jinan, China.
  • Liu XM; Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, Jinan, China.
Cell Death Dis ; 14(11): 779, 2023 11 27.
Article en En | MEDLINE | ID: mdl-38012141
Mitochondria have been identified to be involved in oxidative phosphorylation, lipid metabolism, cell death, and cell proliferation. Previous studies have demonstrated that mitoguardin (Miga), a mitochondrial protein that governs mitochondrial fusion, mitochondria-endoplasmic reticulum (ER) contacts, lipid formation, and autophagy, is crucial for ovarian endocrine and follicular development. Nevertheless, whether mammalian MIGA1 or MIGA2 (MIGA1,-2) regulates ovarian granulosa cell proliferation remains unclear. This study revealed that mammalian MIGA1,-2 promotes cell proliferation and regulates the phosphorylation and localization of Yes-associated protein 1 (YAP1) in ovarian granulosa cells. MIGA2 upregulation resulted in reduced YAP1 activity, while MIGA2 removal led to increased YAP1 activity. Further analysis indicated that MIGA1,-2 regulated YAP1 via the Hippo signaling pathway and regulated protein kinase B (AKT) activity in collaboration with YAP1. In addition, lysophosphatidic acid (LPA) regulated MIGA2 expression and AKT activity by activating YAP1. Briefly, we demonstrated that the mitochondrial MIGA1 and MIGA2, especially MIGA2, promoted cellular proliferation by activating AKT and regulating the Hippo/YAP1 signaling pathway in ovarian granulosa cells, which may contribute to the molecular pathogenesis of reproductive endocrine diseases, such as polycystic ovary syndrome (PCOS).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome del Ovario Poliquístico / Proteínas Mitocondriales / Proteínas Proto-Oncogénicas c-akt / Proteínas de la Membrana Límite: Animals / Female / Humans Idioma: En Revista: Cell Death Dis Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome del Ovario Poliquístico / Proteínas Mitocondriales / Proteínas Proto-Oncogénicas c-akt / Proteínas de la Membrana Límite: Animals / Female / Humans Idioma: En Revista: Cell Death Dis Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido