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Four New Pentacyclic Triterpene Glycosides Isolated from the Fruits of Cryptolepis buchananii R.Br. ex Roem. & Schult and Their Inhibition of NO Production in LPS-activated RAW264.7 Cells.
Duc Duy, Nguyen; Anh Bang, Ngo; Hai Yen, Pham; Thi Trang, Do; Thi Nha Trang, Bui; Thi Kim Thuy, Nguyen; Thi Cuc, Nguyen; Xuan Nhiem, Nguyen; Van Kiem, Phan; Khac Ban, Ninh; Huu Tai, Bui.
Afiliación
  • Duc Duy N; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
  • Anh Bang N; Center for High Technology Development, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
  • Hai Yen P; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
  • Thi Trang D; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
  • Thi Nha Trang B; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
  • Thi Kim Thuy N; Hanoi University of Natural Resources and Environment, 41 A Phu Dien, North Tu Liem, Hanoi, 10000, Vietnam.
  • Thi Cuc N; Center for High Technology Development, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
  • Xuan Nhiem N; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
  • Van Kiem P; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
  • Khac Ban N; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
  • Huu Tai B; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
Chem Biodivers ; 20(12): e202301683, 2023 Dec.
Article en En | MEDLINE | ID: mdl-38012075
From the methanol extract of the Cryptolepis buchananii fruits, four undescribed pentacyclic triterpenene glycosides (1-4) and five known pentacyclic triterpenenes (5-9) were isolated. Their structures were determined to be uncargenin C 28-O-α-L-rhamnopyranosyl-(1→2)-ß-D-glucopyranosyl ester (1), 3-O-ß-D-glucopyranosyluncargenin C 28-O-α-L-rhamnopyranosyl-(1→2)-ß-D-glucopyranosyl ester (2), 3-O-ß-D-glucopyranosyl-(1→6)-ß-D-glucopyranosyl-6ß,23-dihydroxyursolic acid 28-O-α-L-rhamnopyranosyl-(1→2)-ß-D-glucopyranosyl ester (3), 3-O-ß-D-glucopyranosyl-(1→2)-ß-D-glucopyranosylasiatic acid 28-O-α-L-rhamnopyranosyl-(1→2)-ß-D-glucopyranosyl ester (4), asiatic acid (5), 2α,3ß,23-trihydroxyoleana-11,13(18)-dien-28-oic acid (6), arjunolic acid (7), 6ß-hydroxyarjunolic acid (8), and actinidic acid (9) based on analyses of their HR-ESI-MS, 1D and 2D NMR spectra. All the isolates showed significantly NO production inhibition in LPS-activated RAW264.7 cells with the IC50 values ranging from 18.79 to 37.57 µM, compared to that of the positive control compound, dexamethasone, which showed IC50 value of 14.05 µM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saponinas / Triterpenos Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saponinas / Triterpenos Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Suiza