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Catalytic Potential of Cannabis Prenyltransferase to Expand Cannabinoid Scaffold Diversity.
Tanaya, Ryosuke; Kodama, Takeshi; Lee, Yuan-E; Yasuno, Yoko; Shinada, Tetsuro; Takahashi, Hironobu; Ito, Takuya; Morita, Hiroyuki; Awale, Suresh; Taura, Futoshi.
Afiliación
  • Tanaya R; Institute of Natural Medicine, University of Toyama, Sugitani, Toyama 930-0194, Japan.
  • Kodama T; Institute of Natural Medicine, University of Toyama, Sugitani, Toyama 930-0194, Japan.
  • Lee YE; Institute of Natural Medicine, University of Toyama, Sugitani, Toyama 930-0194, Japan.
  • Yasuno Y; Graduate School of Science, Osaka City University, Sumiyoshi, Osaka 558-8585, Japan.
  • Shinada T; Graduate School of Science, Osaka City University, Sumiyoshi, Osaka 558-8585, Japan.
  • Takahashi H; Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
  • Ito T; Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka 584-8540, Japan.
  • Morita H; Institute of Natural Medicine, University of Toyama, Sugitani, Toyama 930-0194, Japan.
  • Awale S; Institute of Natural Medicine, University of Toyama, Sugitani, Toyama 930-0194, Japan.
  • Taura F; School of Pharmacy, Iwate Medical University, Yahaba, Iwate 028-3694, Japan.
Org Lett ; 25(48): 8601-8605, 2023 12 08.
Article en En | MEDLINE | ID: mdl-38010421
Biologically active cannabinoids are derived from cannabigerolic acid (CBGA), which is biosynthesized by aromatic prenyltransferase CsPT4. We exploit the catalytic versatility of CsPT4 to synthesize various CBGA analogues, including a geranylated bibenzyl acid, the precursor to bibenzyl cannabinoids of liverwort origin. The synthesized natural and new-to-nature cannabinoids exhibit potent cytotoxicity in human pancreatic cancer cells. CsPT4 can artificially extend the cannabinoid biosynthetic diversity with novel and improved biological activities.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bibencilos / Cannabinoides / Cannabis / Dimetilaliltranstransferasa Límite: Humans Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bibencilos / Cannabinoides / Cannabis / Dimetilaliltranstransferasa Límite: Humans Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos